Nanoclay Drug Delivery System

Abstract

 The concept is based on the recognition that nanometer sized inert inorganic particles, such as nanometer sized clay particles, can be incorporated into a polymeric host carrier, in order to control the diffusion rate of a dispersed slow-release material. A nano-clay particle reduces the porosity of the polymer, or otherwise obstructs the diffusion of the active material being released, thereby increasing the length of the path of the diffusion through the host polymer. This further slows the rate of release of the slow-release material. Clay minerals are widely used materials in drug products both as excipients and active agents. Drug–clay interactions have been observed as a possible mechanism to modify drug release and/or target drug release or even improve drug dissolution. Finally, new strategies are reported for increasing drug stability and simultaneously modifying drug delivery patterns through the use of clay minerals.