Various Screening Methods for Anti-allergic Activity: An Overview
DOI:
https://doi.org/10.37285/ijpsn.2010.3.2.2Abstract
Development of compounds having diverse antiallergic activities to be used in the treatment of various conditions like rhinitis, dermatitis, asthma, food allergies and pollenosis, requires screening methods with efficient reproducibility and perfection. In such process some series of steps were followed; Antiasthmatic and relative activities were performed on albino guinea pig and isolated trachea through sensitization of animals with well known antigens such as egg albumin and Bordetella pertusis vaccine. Bronchodilator activities for both compound and standard (aminophyline) against contraction were produced by standard agonists like acetylcholine, histamine and egg albumin. Bronchoprotective activities were performed against various mediators. Experiments on sensitized isolated ileum, mast cell stabilizing activities on rat mesenteries, homologous passive cutaneous anaphylaxis (PCA) using above mentioned antigens were followed. Histamine release measurement using human basophilic cell line, KU812 suspension, biological assays using goat antimouse Immunoglobulin E (GAME) and biotinylated GAME, murine and human recombinant Interleukin 4(IL4) antimouse and antihuman CD40 antibodies for ex vivo Immunoglobulin E (IgE) assay, IgE response in human cells and finally in vivo IgE response, Ig ELISA and cytokine assay were performed. Thus after successful completion of such studies it might be possible to establish a versatile antiallergic compound. Some of these studies are discussed here.
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Keywords:
Antiallergic, IgE, Interleukin, Histamine, Screening, Assay
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