Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000
DOI:
https://doi.org/10.37285/ijpsn.2010.3.2.8Abstract
The purpose of this study was to prepare and characterize solid dispersions of the antibacterial agent Cefdinir with PEG 4000 and PVP K-30 with a view to improve its dissolution properties. Investigations of the properties of the dispersions were performed using release studies, X-ray powder diffraction (XRD) and Fourier transform infrared (FTIR). The results obtained showed that the rate of dissolution of Cefdinir was considerably improved when formulated in solid dispersions with PVP K-30 and PEG 4000 as compared with pure drug and physical mixtures. The results from XRD studies showed the transition of crystalline nature of drug to amorphous form, while FTIR studies demonstrated the absence of drug-carriers interaction.
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Keywords:
Solid dispersion, Cefdinir, PVP K-30, PEG 4000, solvent evaporation, melt-fusion
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