N-Substituted Quinazolin- 2,4-diones as Adenosine Receptor Ligands

DOI:

https://doi.org/10.37285/ijpsn.2010.3.2.16

Authors

  • Shireesha B
  • G.V. Kumar
  • V M Reddy
  • Raghuprasad M
  • A R Rao

Abstract

Six new N-substituted quinazolinones were synthesized and evaluated for their adenosine antagonistic activity using allergic mice model where 1, 3-dibenzyl and 1, 3-dibutyl-quinazolindiones were found to be potent than 1, 3-dimethylanalogues. They were not significant in controlling the neutrophil and lymphocyte count but effective in controlling the eosinophil influx. In adenosine receptor binding studies, 1,3-dimethyl and 1,3-dibutyl derivatives were found to have significant adenosine A1 receptor binding efficiency with Ki values 9nM and 10nM, respectively, while 1,3- dibenzyl-quinazolinone was found to have significant binding to adenosine A2A receptor showing the influence of alkyl and aralkyl groups present in these compounds. Thus, the present work indicates the possibility to explore quinazolindiones as adenosine receptor ligands.

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Keywords:

Adenosine ligands, N-alkyl quinazolin-diones, Allergic mice model, Radioligand binding studies

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Published

2010-08-31

How to Cite

1.
B S, Kumar G, Reddy VM, M R, Rao AR. N-Substituted Quinazolin- 2,4-diones as Adenosine Receptor Ligands. Scopus Indexed [Internet]. 2010 Aug. 31 [cited 2024 Dec. 23];3(2):1015-21. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/509

Issue

Vol. 3 No. 2 (2010): July-September 2010

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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