Magnetic Nanoparticles – A Review
DOI:
https://doi.org/10.37285/ijpsn.2010.3.3.1Abstract
In the recent past, the targeted drug delivery has gained more attention for various advantages. Amongst the plethora of avenues explored for targeted drug delivery, magnetic nanoparticles backed foremost attention offering local drug delivery, reduced side effects and controlled drug release for prolonged period of time addressing problems of healthy tissue damage, drug wastage. An approach was made herein to review the history of magnetic guidance, concept of magnetic nanoparticles, their advantages, methods of preparation, characterization, applications explored in various fields of drug delivery. This review also deals up with the disadvantages of magnetic nanoparticles, the alternative way to overcome. It also focuses on exemplifying different drug formulations formulated into magnetic nanoparticles.Future prospectives, challenges faced in drug delivery and scope of magnetic nanoparticles have also been addressed.
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magnetic nanoparticles, magnetic drug targeting, drug targeting, super paramagnetism
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Abdalla, M.O.; Aneja, R.; Dean, D.; Rangari, V.; Russell, A.; Jaynes, J.; Yates, C.; Turner, T. Synthesis and characterization of noscapine loaded magnetic polymeric nanoparticles. J. Magn. Magn. Mater. 2010, 322, 190-196.
Amara, D.; Felner, I.; Nowik, I.; Margel, S. Synthesis and characterization of Fe and Fe3O4 nanoparticles by thermal decomposition of triiron dodecacarbonyl. Colloids Surf. A: Physicochem. Eng. Aspects 2009, 339, 106-110.
Arias, J.L.; Gallardo, V.; Ruiz, M.A.; Delgado, A.V.; Magnetite/poly (alkylcyanoacrylate) (core/shell) nanoparticles as 5-Fluorouracil delivery systems for active targeting. Eur. J. Pharm. Biopharm. 2008, 69, 54-63.
Aslam, K. Preparation and characterization of magnetic nanoparticles embedded in microgels. Mater. Lett. 2008, 62, 898–902.
Aviles, M.O.; Mangual, J.O.; Ebner, A.D.; Ritter, J.A. Isolated swine heart ventricle perfusion model for implant assisted-magnetic drug targeting. Int. J. Pharm. 2008, 361, 202-208.
Bai, L.; Wan, H.; Shane Street, C. Preparation of ultrafine FePt nanoparticles by chemical reduction in PAMAM-OH template. Colloids Surf. A: Physicochem. Eng. Aspects 2009, 349, 23-28.
Berry, C.C.; Charles, S.; Wells, S.; Dalby, M.J.; Curtis, A.S.G. The influence of transferrin stabilised magnetic nanoparticles on human dermal fibroblasts in culture. Int. J. Pharm. 2004, 269, 211–225.
Berry, C.C.; Wells, S.; Charles, S.; Curtis, A.S.G. Dextran and albumin derivatised iron oxide nanoparticles: influence on fibroblasts in vitro. Biomaterials 2003, 24, 4551–4557.
Bi, F.; Zhang, J.; Su, Y.; Tang, Y.C.; Liu, J.N. Chemical conjugation of urokinase to magnetic nanoparticles for targeted thrombolysis. Biomaterials 2009, 30, 5125–5130.
Chen, D.H.; Liao, M.H. Preparation and characterization of YADH-bound magnetic nanoparticles. J. Mol. Catal. B Enzymatic 2002, 16, 283–291.
Chen, J.; Wu, H.; Han, D.; Xie, C. Using anti-VEGF McAb and magnetic nanoparticles as double-targeting vector for the radioimmunotherapy of liver cancer. Cancer Lett. 2006, 231, 169-175.
Conroy, S.; Jerry Lee, S.H.; Zhang, M. Magnetic nanoparticles in MR imaging and drug delivery. Adv. Drug Deliv. Rev. 2008, 60, 1252–1265.
Cregg, P.J.; Murphy, K.; Mardinoglu, A. Inclusion of magnetic dipole–dipole and hydrodynamic interactions in Implant-assisted magnetic drug targeting. J. Magn. Magn. Mater. 2009, 321, 3893–3898.
Dormer, K.; Seeney, C.; Lewelling, K.; Lian, G.; Gibson, D.; Johnson, M. Epithelial internalization of superparamagnetic nanoparticles and response to external magnetic field. Biomaterials 2005, 26, 2061–2072.
Du, X.; Inokuchi, M.; Toshima, N. Preparation and characterization of Co–Pt bimetallic magnetic nanoparticles. J. Magn. Magn. Mater. 2006, 299, 21-28.
Fu, W.; Yang, H.; Bala, H.; Liu, S.; Li, M.; Zou, G. Preparation and magnetic characterization of core–shell structure stainless steel/silica nanoparticles. Mater. Lett. 2006, 60: 1728–1732.
Gaihrea, B.; Khil, MS.; Lee, D.R.; Kim, H.Y. Gelatin-coated magnetic iron oxide nanoparticles as carrier system: Drug loading and in vitro drug release study. Int. J. Pharm. 2009, 365, 180-189.
Garcia-Cerda, L.A.; Torres-Garcia, V.A.; Matutes-Aquino, J.A.; Ayala-Valenzuela, O.E. Magnetic nanocomposites: preparation and characterization of Co-ferrite nanoparticles in a silica matrix. J. Alloys Compd. 2004, 369, 148–151.
Gupta, A.K.; Gupta, M. Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. Biomaterials 2005, 26, 3995–4021.
Hong, R.Y.; Feng, B.; Chen, L.L.; Liu, G.H.; Li, H.Z.; Zheng, Y.; Wei, D.G. Synthesis, characterization and MRI application of dextran-coated Fe3O4 magnetic nanoparticles. Biochem. Eng. J. 2008, 42, 290-300.
Hong, R.Y.; Zhang, S.Z.; Di, G.Q.; Li, H.Z.; Zheng, Y.; Ding, J.; Wei, D.G.; Preparation, characterization and application of Fe3O4/ZnO core/shell magnetic nanoparticles. Mater. Res. Bull. 2008, 43, 2457–2468.
Huang, G.; Diakur, J.; Xu, Z.; Wiebe, L.I. Asialoglycoprotein receptor-targeted superparamagnetic iron oxide nanoparticles. Int. J. Pharm. 2008, 360, 197–203.
Ito, A.; Shinkai, M.; Honda, H.; Kobayashi, T. Medical Application of Functionalized Magnetic Nanoparticles. J. Biosci. Bioeng. 2005, 100, 1-11.
Jain, T.K.; Richey, J.; Strand, M.; Pelecky, D.L.L.; Flask, C.A.; Labhasetwar, V. Magnetic nanoparticles with dual functional properties: Drug delivery and magnetic resonance imaging. Biomaterials 2008, 29, 4012–4021.
Jia, Z.; Yujun, W.; Yangcheng, L.; Jingyu, M.; Guangsheng, L. In situ preparation of magnetic chitosan/Fe3O4 composite nanoparticles in tiny pools of water-in-oil microemulsion. React. Funct. Polym. 2006, 66, 1552–1558.
Lee, D.K.; Kang, Y.S. Preparation and characterization of magnetic nanoparticles by ۷-irradiation. Mater. Sci. Eng. C 2004, C 24, 107-111.
Li, G.Y.; Huang, K.L.; Jiang, Y.R.; Ding, P.; Yang, D.L. Preparation and characterization of carboxyl functionalization of chitosan derivative magnetic nanoparticles. Biochem. Eng. J. 2008, 40, 408–414.
Li, G.Y.; Huang, K.L.; Jiang, Y.R.; Ding, P.; Yang, D.L. Preparation and characterization of Saccharomyces cerevisiae alcohol dehydrogenase immobilized on magnetic nanoparticles. Int. J. Biol. Macromol. 2008, 42, 405–412.
Li, G.Y.; Jiang, Y.R.; Huang, K.L.; Ding, P.; Chen, J. Preparation and properties of magnetic Fe3O4–chitosan nanoparticles. J. Alloys Compd. 2008, 466, 451-456.
Li, G.Y.; Jiang, Y.R.; Huang, K.L.; Ding, P.; Yao, L.L. Kinetics of adsorption of Saccharomyces cerevisiae mandelated dehydrogenase on magnetic Fe3O4–chitosan nanoparticles. Colloids Surf. A: Physicochem. Eng. Aspects 2008, 320, 11-18.
Ma, H.L.; Qi, X.R.; Maitani, Y.; Nagai, T. Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate. Int. J. Pharm. 2007, 333, 177-186.
Mak, S.Y.; Chen, D.H. Fast adsorption of methylene blue on polyacrylic acid-bound iron oxide magnetic nanoparticles. Dyes and Pigments 2004, 61, 93–98.
Martin, A.R.; Finlay, W.H. Enhanced deposition of high aspect ratio aerosols in small airway bifurcations using magnetic field alignment. J. Aerosci. 2008, 39, 679 – 690.
Morais, P.C.; Santos, R.L.; Pimenta, AC.M.; Azevedo, R.B.; Lima, E.C.D. Preparation and characterization of ultra-stable biocompatible magnetic fluids using citrate-coated cobalt ferrite nanoparticles. Thin Solid Films 2006, 515, 266-270.
Munnier, E.; Jonathan, S.C.; Linassier, C.; Eyrolles, L.D.; Marchais, H.; Herve, S.K.; Dubois, P.; Chourpa, I. Novel method of doxorubicin–SPION reversible association for magnetic drug targeting. Int. J. Pharm. 2008, 363, 170–176.
Ning, L.; Xiaojie, L.; Xiaohong, W.; Honghao, Y.; Fei, M.; Wei, S.; Preparation and magnetic behavior of carbon-encapsulated iron nanoparticles by detonation method. Comp. Sci. Technol. 2009, 69: 2554–2558.
Qiu, J.D.; Xiong, M.; Liang, R.P.; Peng, H.P.; Liu, F. Synthesis and characterization of ferrocene modified Fe3O4@Au magnetic nanoparticles and its application. Biosens. Bioelectron. 2009, 24, 2649–2653.
Schulze, K.; Koch, A.; Schopf, B.; Petri, A.; Steitz, B.; Chastellain, M.; Hofmann, M.; Hofmann, H.; Rechenberg, B.V.; Intraarticular application of superparamagnetic nanoparticles and their uptake by synovial membrane—an experimental study in sheep. J. Magn. Magn. Mater. 2005, 293, 419–432.
Shaw, S.Y.; Chen, Y.J.; Ou, J.J.; Ho, L. Preparation and characterization of Pseudomonas putida esterase immobilized on magnetic nanoparticles. Enzyme Microb. Technol. 2006, 39, 1089–1095.
Shen, Y.F.; Tang, J.; Nie, Z.H.; Wang, Y.D.; Renc, Y.; Zuo, L. Preparation and application of magnetic Fe3O4 nanoparticles for wastewater purification. Sep. Purif. Technol. 2009, 68, 312–319.
Sun, J.B.; Duan, J.H.; Dai, S.L; Ren, J.; Zhang, Y.D.; Tian, J.S.; Li, Y. In vitro and in vivo antitumor effects of doxorubicin loaded with bacterial magnetosomes (DBMs) on H22 cells: The magnetic bio-nanoparticles as drug carriers. Cancer Lett. 2007, 258, 109-117.
Tartaj, P.; Morales, M.P.; Veintemillas-Verdaguer, S.; Teresita Gonzalez-Carreno, T.; Carlos Serna, J. The preparation of magnetic nanoparticles for applications in biomedicine. J. Phys. D: Appl. Phys. 2003, 36, R182–R197.
Vekas, L.; Bica, D.; Avdeev, M.V. Magnetic nanoparticles and concentrated magnetic nanofluids: Synthesis, properties and some applications. China Particu. 2007, 5, 43-49.
Wang, S.; Yang, Z.; Sun, W. Preparation and characterization of antifouling thermosensitive magnetic nanoparticles for applications in biomedicine, Mater. Sci. Engin. C 2009, C (29), 1196–1200.
Wang, X.; Wang, L.; He, X.; Zhang, Y.; Chen, L. A molecularly imprinted polymer-coated nanocomposite of magnetic nanoparticles for estrone recognition. Talanta. 2009, 78, 327–332.
Wu, Y.; Wang, Y.; Luo, G.; Dai, Y. In situ preparation of magnetic Fe3O4-chitosan nanoparticles for lipase immobilization by cross-linking and oxidation in aqueous solution. BioRes. Technol. 2009, 100, 3459–3464.
Xu, H.; Song, T.; Bao, X.; Hu, L. Site-directed research of magnetic nanoparticles in magnetic drug targeting. J. Magn. Magn. Mater. 2005, 293, 514–519.
Xu, J.; Yang, H.; Fu, W.; Du, K.; Sui, Y.; Chen, J.; Zeng, Y.; Li, M.; Zou, G.; Preparation and magnetic properties of magnetite nanoparticles by sol–gel method. J. Magn. Magn. Mater. 2007, 309, 307-311.
Yamaura, M.; Camilo, R.L.; Sampaio, L.C.; Macedo, M.A.; Nakamura, M.; Toma, H.E. Preparation and characterization of (3-aminopropyl) triethoxysilane-coated magnetite nanoparticles. J. Magn. Magn. Mater. 2004, 279, 210-217.
Yang, J.; Park, S.B.; Geun Yoon H.; Huh, Y.M.; Haam, S. Preparation of poly ε-caprolactone nanoparticles containing magnetite for magnetic drug carrier. Int. J. Pharm. 2004, 324, 185–190.
Yang, Y.X.; Liu, M.L.; Zhu, H.; Chen, Y.R.; Mu, G.J.; Liu, X.N.; Jia, Y.Q. Preparation, characterization, magnetic property, and Mossbauer spectra of the β-FeOOH nanoparticles modified by nonionic surfactant. J. Magn. Magn. Mater. 2008, 320, L132– L136.
Yong, Y.; Bai, O.; Li, Y.; Lin, L.; Cui, Y.; Xi, C. Preparation and application of polymer-grafted magnetic nanoparticles for lipase immobilization. J. Magn. Magn. Mater. 2008, 320, 2350– 2355.
Zhang, J.; Misra, R.D.K. Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: Core–shell nanoparticle carrier and drug release response. Acta Biomater. 2007, 3, 838–850.
Zhang, L.Y.; Zhu, X.J.; Sun, H.W.; Chi, G.R.; Xu, J.X.; Sun, Y.L. Control synthesis of magnetic Fe3O4–chitosan nanoparticles under UV irradiation in aqueous system. Curr. Appl. Phys. 2010, 10, 828–833.
Zhao, Y.; Qiu, Z.; Huang, J. Preparation and Analysis of Fe3O4 Magnetic Nanoparticles Used as Targeted-drug Carriers. Chinese J. Chem. Eng. 2008, 16 (3), 451-455.
Zhu, L.; Ma, J.; Jia, N.; Zhao, Y.; Shen, H.; Chitosan-coated magnetic nanoparticles as carriers of 5-Fluorouracil: Preparation, characterization and cytotoxicity studies. Colloids Surf. B: Biointerfaces 2009, 68, 1-6.
