Studies in Optimization of Aqueous Film Coating Parameters

DOI:

https://doi.org/10.37285/ijpsn.2009.2.3.5

Authors

  • Navin Sheth
  • Sunny Shah
  • Arti Potdar
  • Anand Shah

Abstract

The purpose of this research was to study the aqueous-based film coating of tablets utilizing a laboratory-scale side-vented perforated pan-coating apparatus. The process parameters of potential importance with respect to the final film quality were evaluated by using trial and error method. Tablets were evaluated for coating uniformity (mg), coating process efficiency (%), surface roughness, and %LOD (loss on drying). Spray rate and inlet air temperature both affect the all characteristic of coated tablets. Rotating speed of pan mainly affect the coating uniformity of tablets. % Solid content affects the surface of coated tablets and also creates a problem in spray flow. The process parameters relevant to a side-vented perforated pan coating process can be identified and, consequently, optimized.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

Aqueous film coating, Coating uniformity, Coating process efficiency, Perforated pan coating.

Downloads

Published

2009-11-30

How to Cite

1.
Sheth N, Shah S, Potdar A, Shah A. Studies in Optimization of Aqueous Film Coating Parameters. Scopus Indexed [Internet]. 2009 Nov. 30 [cited 2024 Nov. 22];2(3):621-6. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/529

Issue

Vol. 2 No. 3 (2009): October-December 2009

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Cole GC. Pharmaceutical Coating Technology, Taylor and Francis Ltd, 1998) pp.6-52.

Dansereau R., Brock, M. and Furey-Redman N. Solubilization of drug and excipient into a hydroxypropyl methylcellulose (HPMC)-based film coatings as a function for the coating parameters in a 24" Accela-Cota. Drug Dev. Ind. Pharm. 19: 793-808 (1993).

Franz RM, and Doonan GW. Measuring the surface temperature of tablet beds using infrared thermometry. Pharm Technol. 7: 55-67 (1983).

M. Ruotsalainen et al, Studies on Aqueous Film Coating of Tablets in Side Vented Perforated Pan Coater, ISBN 352-10-1041-X, Helsinki, (2003).

Obara S. and McGinity, JW. Influence of processing variables on the properties of free films prepared from aqueous polymeric dispersions by a spray technique. Int. J. Pharm. 126: 1-10 (1995).

Optimal Coating Process Parameters for a New, Fully-Formulated, Acrylic-based, Enteric, Film-Coating System, American Association of Pharmaceutical Scientists, November (2000).

Porter SC, Verseput RP, and Cunningham CR. Process optimization using design of experiments. Pharm. Technol. 21: 60-70 (1997).

Porter, Bruno, Coating of pharmaceutical solid-dosage forms, Pharm. Tech., 4(3): 66 (1980).

Poukavoos N, and Peck GE. Effect of aqueous film coating conditions on water removal efficiency and physical properties of coated tablet cores containing superdisintegrants. Drug Dev. Ind. Pharm. 20: 1535-1554 (1994).

Skultety PF, Rivera D, Dunleavy J. and Lin CT. Quantification of the amount and uniformity of aqueous film coating applied to tablets in a 24" Accela-Cota. Drug Dev. Ind. Pharm. 14: 617-631 (1988).

Tobiska S, and Kleinbudde P. A simple method for evaluating the mixing efficiency of a new type of pan coater. Int. J. Pharm. 224: 141-149 (2001).

Twitchell AM, Hogan JE, and Aulton ME, Assessment of the Thickness variation and Surface roughness of Aqueous Film Coated Tablets using a light-section microscope, Drug Dev. Ind. Pharm. 21: 1611-1619 (1995b).

Twitchell AM, Hogan JE, and Aulton ME. The behaviour of film coating droplets on the impingement onto uncoated and coated tablet. S.T.P. Pharm. Sci. 5: 190-195. (1995a).

Wilson KE, and Crossman E. The influence of tablet shape and pan speed on intra-tablet film coating uniformity. Drug Dev. Ind. Pharm. 23: 1239-1243 (1997).