Synthesis of Cyanoacetylated Derivatives of Some Heteroaryl Amines as Analgesic and Antioxidant Agents
DOI:
https://doi.org/10.37285/ijpsn.2012.5.4.8Abstract
There are several drugs in the clinical practice that contain the cyanoacetyl moiety. In the present study, we prepared cyanoacetylated derivatives of some aryl/hetero aryl amines by using a versatile cyanoacetylating agent, 1-cyanoacetyl-3,5-dimethylpyrazole. These compounds were evaluated for analgesic activity by the acetic acid induced writhing test. The compounds were also evaluated for antioxidant activity by reduction of DPPH, scavenging of nitric oxide, and iron-induced lipid peroxidation in rat brain homogenate. Among several compounds synthesized and evaluated, ethyl-2-(α-cyanoacetamido)-4,5-dimethylthiophene-3-carboxylate exhibited potent analgesic and antioxidant activity, which is comparable to the standard drug employed. These compounds have promising potential as potential analgesic and antioxidant agents.
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Keywords:
SAR, Cyanoacetylating agent, 1-Cyanoacetyl-3, 5-dimethylpyrazole, Analgesic activity, Antioxidant activity
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