The Role of Transient Receptor Potential Vanilloid 1 (TRPV1) in Enalapril-Induced Airway Hyperresponsiveness in Mouse Model
DOI:
https://doi.org/10.37285/ijpsn.2013.6.2.5Abstract
Airway hyperresponsiveness is an important pathophysiological feature of asthma. Transient Receptor Potential Vanilloid-1 (TRPV1) receptor expression is increased under asthma and activation of TRPV1 plays a key role in the manifestation of airway hyperresponsiveness. Various inflammatory mediators (prostaglandin E2, bradykinin etc.) enhance sensitivity and reduce the activation threshold of TRPV1 receptor. Enalapril is an Angiotensin-converting enzyme (ACE) inhibitor often associated with airway hyperresponsiveness in asthmatic hypertensive patients through an increase in bradykinin level. Therefore, the present investigation is carried out to find out the role of TRPV1 in enalapril-induced airway hyperresponsiveness using trypsin and egg-albumin induced asthma model mice. Enalpril,baicalein, celecoxib and capsazepine were administered for 8 days and airway hyperresponsiveness was measured in terms of tidal volume, respiratory rate, and airflow rate. There was significantly lower tidal volume and airflow rate and higher respiratory rate in enalapril treated asthmatic mice compared to only asthmatic mice. Mice pretreated with capsazepine, celecoxib, and baicalein before 2 h of enalapril administration showed significantly increased tidal volume and airflow rate, and decreased respiratory rate compared to enalapril-treated asthmatic mice. Thus, it is concluded that TRPV1 might be involved in enalapril-induced airway hyperresonsiveness in asthmatic mice. The cycloxygenase and 12-lipoxygenase pathways might be involved in activation of TRPV1 by enalapril.
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Airway hyperresponsiveness, asthma, TRPV1, enalpril, bradykinin, ACE inhibitors
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