Formulation Development of Oral Mucoadhesive Tablets of Losartan Potassium using Mucilage Isolated from Diospyros melonoxylon Roxb Seeds
DOI:
https://doi.org/10.37285/ijpsn.2013.6.3.7Abstract
Diospyros melonoxylon Roxb is a small tree with rather slender stem and smooth grey bark belonging to family Ebenaceae found widely in Chhattisgarh. The present investigation reports the isolation of mucilage from Diospyros melonoxylon seeds as per AOAC guideline and evaluating it as mucoadhesive agent. Physiochemical characteristics of mucilage, such as appearance, solubility, swelling index, microbial count, loss on drying, viscosity, hydration capacity, flow property, hausner ratio and pH were studied. The mucilage was evaluated for its mucoadhesive properties in compressed tablet, using Losartan Potassium as model drug. Granules were prepared by wet granulation process using polyvinylpirroli-done as binding agent. Mucilage was used in four different concentrations i.e. 20, 40 and 60 % w/w. The prepared granules were evaluated for micrometrics property. The tablet were prepared and evaluated for weight variation, thickness diameter, hardness, percent friability, in vitro dissolution and degree of swelling. The property of bioadhesive strength of isolated mucilage was compared with Guar Gum and HPMC E5LV, which was used as standard mucoadhesive agent concentration. Bioadhesive strength of the tablet was measured on the modified physical balance. The tablets had good physiochemical properties, and drug release was retarded as concentration of mucilage was increased. The force of adhesion was obtained 0.2063N, 0.3837N, 0.5175N, 0.8679N and 0.3983N respectively for F1, F2, F3, F4 and F5. Formulations were subjected for study of effect of intensity of agitation at different rpm (50 and 150) and electrolyte (NaCl and CaCl2), and formulation showed relative effect on release of drug from formulation. All the formulations were subjected to stability studies for three months all formulation showed stability with respect to release pattern.
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Diospyros melonoxylon, Mucoadhesive agent, Mucilage, Natural Gum
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Achanta Raviteja, Chandra S, Partiben K G, Naveen Raja Kante and Devareddy Sandeep (2012). Development and in vitro evaluation of buccoadhesive tablets of Losartan Potassium. Int. Res J. Pharm. 3(9): 277-281.
Achar L and Pepass N (1994). Preparation, Characterization and mucoadhesive interaction of poly (methacrylic acid) copolymer with rate mucosa. J Control Release 31: 271-276.
Amin and Kohli (2003). Stability studies The Indian Pharmacist 11 - 12.
Andreas B S (2005). Mucoadhesive systems in oral drug delivery. Drug Discov Today Technol, 2(1): 85-87.
Association of Official Analytical Chemists (AOAC) (1990). Official Methods of Analysis. 15th ed. Washington DC USA.
Atul K and Jain N K (2006). Formulation and in vitro, in vivo evaluation of extended release matrix tablet of Zidovudin. AAPS Pharm Science Tech 1: 1-17.
Banker S G and Rhodes C T (2009). Modern Pharmaceutics, 4th ed. Informa Health Care USA 167-184.
Bhardwaj T R, Kanwar M and Lal R (2000). Natural gums and modified natural gums as sustained release carriers. Drug Dev Ind Pharm 26(10): 1025-1038.
British pharmacopeia (1993). London. Hal and Chapman 2: A157.
Chandrasekara MJN, Mahesh Kumara S, Manikandanb D and Nanjanb MJ (2011). Isolation and evaluation of a polysaccharide from Prunus amygdalus as a carrier for transbuccosal delivery of Losartan potassium. Int J Biol Macromo 48: 773–778.
Chickering D E and Mathiowitz E (1999). Fundamental of bioadhesion. In: Lehr CM, editor. Bioadhesive drug delivery system-fundamentals, Novel Approach and Development. New York: Marcel Dekker 1-85.
Colombo P, Conte U, Gazzaniga A, Maggi L, Sangalli M E, Peppas N A and La Manna A (1990). Drug release modulation physical restriction of matrix swelling. Int J PharmSci 63(1): 43-48.
Desai A, Shidhaye S and Malke S (2005). Use of natural release retardant in drug delivery system. Indian Drugs 42: 565 - 575.
Deshmukh V N, Jadhav J K and Sakarkar D M (2009). Formulation and in vitro evaluation theophylline anhydrous bioadhesive, Asian J Pharm 3(1): 54-58.
Dhiren P Shah and Jani G K (2009). Modification and Characterization of Gellan Gum. Pharmaceutical Technology 32(2): 48-58.
Dhiren P Shah and Jani G K (2009). Seed mucilage of Blepharis edulis as disintegrant in tablet: extraction, formulation and evaluation. Acta Pharm. Sciencia 51(4): 271-280.
Hussein Omidian, Seyed-Ali Hasherni, Fahinieh Askari, Siavash Nafisi (1994). Swelling and Crosslink Density Measurements for Hydrogels, Iranian J Polymer Science and Technology (3)2: 115-119.
International Conference on Harmonization (ICH) guidelines (2005). Department of Health and Human Services, Design for stability testing of new drug substance and products 2339 - 2340.
Ishrat N, Jakir A C, Mia M D and Selim M R (2005). Effect of electrolytes on release of diclofenac sodium from Agarose beads. Dhaka University Journal Pharma Science 4(2): 117-120.
Jain D K, Darwhekar G N and Chaurasia S (2012). Formulation development and evaluation of transdermal patches of Losartan Potassium. Int. J PharmTech Res. 4(2): 757-764,
Jani G K, Shah D P, Jain V C, Patel M J and Vithalani D A (2007). A Preliminary investigation on gum of Anogeissus latifolia wall as a pharmaceutical excipient. Int. J Pharm. Excipient 3(4): 121-126.
Kimberley J, Young D and Pant S (2000) Drug-excipient interactions and their effect on absorption. Pharm. Sci Tech. 3(10): 336 - 345.
Korsmeryer R W, Gunny R D E, Buri P and Peppas N A (1983). Mechanism of solute release from porous hydrophilic polymers. Int. J Pharm. 15: 25-35.
Kulkarni G T, Gowathamarajan K, Rao B G and Suresh B (2004). Stability testing of Pharmaceutical product: An overview. Ind. J Pharm Sci 38(4): 194-202.
Marina Koland, Charyulu RN and Prabhakara Prabhu (2010). Mucoadhesive films of Losartan Potassium for Buccal delivery: Design and Characterization. Indian J. Pharm. Educ. Res. 44(4): 315-323.
Martin Patrick J Sinko (2010). Physical Pharmacy and pharmaceutical sciences: In Micromeritics, Wolters Kluwer, Lippincott Williams and Wilkins New Delhi, South Asian Edition 6th ed. 451, 461-466, 533-560.
Nakano M, Nakamura Y and Juni K (1980). Sustained release of Sulfamethizole from agar beads after oral administration to humans. Chem Pharm Bull. 28(10): 2905-2908.
Owen Corrigen J (2004). Swelling and erosion properties of HPMC matrices. Int. J Pharm. 279: 141-152.
Patel D B and Patel M M (2009) Natural excipients in controlled drug delivery systems. J Pharm Res 2(5): 900-907.
Paulo C and Jose M S L (2001). Modeling and comparison of dissolution profile. European J Pharm Sci 13: 123-133.
Peppas N A (1985). Analysis of fickian and non-fickian drug release from polymers. Pharma Acta Helv. 60: 110-111.
Perioli L, Ambrogi V, Rubini B, Giovangoli S, Ricci M, Blasi P and Rossi C (2004). Novel mucoadhesive buccal formulation containing metronidazole for the treatment of periodontal disease. J Contr. Rel. 95: 521-533.
Ranga Rao K V and Buri P (1989). A novel in situ method to test polymers and coated micro particles for bioadhesion. Int. J Pharm. 52: 265-270.
Subramanyam C V S (2008). Text book of pharmaceutical, 2nd ed., 211-224.
United States Pharmacopeia, XXVI NF 26 (2008), United State Pharmacopeia Convention, Asian edition, Rockville, Voll- I, 368, USP-28.
Uusitupa M I J (1990). Fiber in the management of diabetes [letter], Br Med J 301: 122.
Vazquaz M J, Perez Macros B, Gomez-Amoza J L and Pepass N A (1992). Influence of technological variables on release of drug from hydrophilic matrices. Drug Delivery Ind. Pharm 18: 1355-1375.
Zaki M A and Bhattacharya (2009). Isolation and physicochemical characterization of Boral rice from Assam as pharmaceutical excipients. J Pharm Res 2(7): 1299-1303.
