Synthesis and Characterization of Aromatic-Heterocyclic Derivatives of Sulphonamides as Potential Antimicrobial Agents
DOI:
https://doi.org/10.37285/ijpsn.2014.7.1.12Abstract
The incidence of microbial infection is increasing world-wide despite active research on the discovery and development of novel anti-microbial agents. Then emergence of multi-resistant strains of bacteria has increased the problem of drug resistance dramatically. The development and use of new anti-microbial agents is one of the ways to combat the emergence of anti-microbial resistance. The literature survey reveals that the sulfonamide derivatives as privileged pharmacophore for wide range of biological activities including anti-microbial activity. So a series of (3a-3e and 6a-6c) sulfonamide derivatives were synthesized by attaching alkyl/ aryl/heterocyclic sulphonyl chloride and alkyl/aryl carbonyl chloride moieties to aromatic sulfonamide incorporating free amino group by Schotten Baumann (SB) reaction. All the synthesized compounds were characterized by FTIR, Mass, and other analytical techniques. The synthesized compounds have been screened against different bacterial (B. subtilis, S. aureus and E. coli) and fungal (A. niger and P. chrysogenum) strains using the cup-plate method. The synthesized sulfonamides derivatives showed significant antibacterial activity against Gram-positive and Gram-negative organisms, while they were found to be inactive against fungal strains. From the results, it is evident that the presence of a hetero/aromatic ring showed good antibacterial activity. Some of these compounds can be considered as potential candidates for treatment of infections caused by Gram-positive as well as Gram-negative bacteria.
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Keywords:
Sulfonamides, ethyl acetate, ethanol, triethylamine, antimicrobial activity
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