Antihyperglycemic Effects of Tragia plukenetii Ethanolic Extract

DOI:

https://doi.org/10.37285/ijpsn.2014.7.2.5

Authors

  • Venkatesh Sama
  • Rajini T
  • Humera Afrooz
  • Balaraju P
  • B. Madhava Reddy
  • Ramesh Mullangi

Abstract

Plants represent a major potential source of drugs for treating diabetes. The study of plants having antidiabetic activity may give a new approach in the treatment of diabetes mellitus. Tragia plukenetii is traditionally claimed to be useful in the treatment of diabetes. The present study was intended to evaluate the antihyperglycemic activity of aqueous ethanolic extract on normal fasted, glucose loaded and alloxan induced diabetic rats, at an oral dose of 75, 150 and 300 mg/kg in male Wistar rats. The alcoholic extract has not produced any hypoglycemia in normal fasted rats. The ethanolic extract has displayed a significant dose dependent antihyperglycemic activity in oral glucose tolerance test and in alloxan induced diabetic rats at an oral dose of 150 and 300 mg/kg. The ethanolic extract has effectively scavenged the stable free DPPH radical in-vitro. It is concluded that Tragia plukenetii aerial parts alcoholic extract is effective in controlling blood glucose levels in diabetic rats.

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Keywords:

Tragia plukenetii, Hypoglycemia, Antidiabetic activity, Alloxan, Glucose, Ethanolic extract, DPPH.

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Published

2014-05-31

How to Cite

1.
Sama V, T R, Afrooz H, P B, Reddy BM, Mullangi R. Antihyperglycemic Effects of Tragia plukenetii Ethanolic Extract. Scopus Indexed [Internet]. 2014 May 31 [cited 2024 Dec. 22];7(2):2436-40. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/711

Issue

Vol. 7 No. 2 (2014): April-June 2014

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

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