Overview of Current Challenges of Nanoparticle Toxicity
DOI:
https://doi.org/10.37285/ijpsn.2014.7.4.1Abstract
Nanomaterials improve everyday products but their safety for human health is poorly known. Due to the complex nature of nanomaterials, conflicting studies have led to different views of their safety. Many nanoparticles used by industry contain heavy metals, thus toxicity and bioaccumulation of heavy metals contained in nanoparticles may become important environmental issues. Due to the fast spreading of nanoproducts in the market, there is an urgent need for new research programs related to the broad area of nanotoxicology. This paper considers the properties of dispersed metallic nanoparticles and highlights the relationship between these nanoparticles and their toxicity.
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Keywords:
Nanoparticle, Nanotechnology, Nanomaterials, Drug delivery, Nanoparticle toxicity
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Aston R, Saffie-Siebert R, Canham L and Ogden J (2005). Nanotechnology Applications for drug delivery. Pharmaceutical Technology Europe 17(4): 21-28.
Ballou B, Lagerholm BC, Ernst LA, Bruchez MP and Waggoner A.S (2004). Noninvasive imaging of quantum dots in mice. Bioconjug Chem 15: 79-86.
Borm PJ (2002). Particle toxicology: from coal mining to nanotechnology. Inhal Toxicol 14: 311-24.
Brook R.D, Franklin B and Cascio W (2004). Air pollution and vascular disease. A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association. Circulation 109: 2655-2671.
Buxton D.B, Lee S.C and Wickline S.A (2003). Recommendations of the National Heart, Lung, and Blood Institute Nanotechnology Working Group. Circulation 108: 2737-2742.
Carty C.L, Gehring U and Cyrys J (2003). Seasonal variability of endotoxin in ambient fine particulate matter. J Environm Monit 5: 953-8.
Chang J.S, Chang K.L.B and Hwang D.F (2007). In vitro cytotoxicity of silica nanoparticles at high concentrations strongly depends on the metabolic activity type of the cell line. Environ Sci Technol 41: 2064-2068.
Cho S.J, Maysinger D and Jain M (2007). Long term exposure to CdTe quantum dots causes functional impairment in living cells. Langmuir 23: 1974-1980.
Dawson NG (2008). Sweating the small stuff: environmental risk and nanotechnology. Bioscience 58(8): 690.
Dockery D.W, Pope C.A and Xu X (1993). An association between air pollution and mortality in six U.S. cities. N Engl J Med 329: 1753-1759.
Donaldson K, Brown D and Clouter A (2002). The pulmonary toxicology of ultrafine particles. J Aerosol Med 15: 213-220.
Duncan R (2003). The dawning era of polymer therapeutics. Nat Rev Drug Disc 2: 347-360.
Duncan R and Izzo L (2005). Dendrimer biocompatibility and toxicity. Adv Drug Deliv Rev 57: 2215-2237.
Ferrari M (2005). Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5: 161-171.
Hardman R (2006). A toxicological review of quantum dots: toxicity depends on physicochemical and environmental factors. Environ Health Perspect 114: 165-172.
Hoshino A, Fujioka K and Oku T (2004). Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Lett 4: 2163-2169.
Jin Y, Kanna S and Wu M (2007). Toxicity of luminescent silica nanoparticles to living cells. Chem Res Toxicol 20: 1126-1133.
Kawano, T.; Yamagata, M.; Takahishi, H (2006). Stabilizing of plasmid DNA in vivo by PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical pulses. J Control Rel 111, 382–389.
Kreuter J, Alyautdin R.N, Kharkevich D.A and Ivanov A.A (1995). Passage of peptides through the blood–brain barrier with colloidal polymer particles (nanoparticles). Brain Res 674: 171-174.
Kreyling W.G, Semmler M and Möller W (2004). Dosimetry and toxicology of ultrafine particles. J Aerosol Med 17: 140-152.
Kreyling W.G, Semmler M and Erbe F (2002). Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J Toxicol Environ Health Part A 65: 1513-1530.
Krishna R.S.M, Shivkumar H.G, Gowda D.V and Banerjee S (2006). Nanoparticles: A novel colloidal drug delivery system. Indian J. Pharm. Res 40(1): 15-21.
Lai M.K, Chang C.Y and Lien Y.W (2006). Application of gold nanoparticles to microencapsulation of thioridazine. J Control Rel 111: 352-361.
Lam C.W, James J.T and McCluskey R (2004). Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77: 126-134.
Lovern S.B, Klaper R (2006). Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles. Environ Toxicol Chem 25: 1132-1137.
Maynard A.D, Aitken R.J, Butz T, Colvin V, Donaldson K, Oberdörster G, Philbert M.A, Ryan J and Seaton A (2006). Safe handling of nanotechnology. Nature 444: 267-269.
Mills N.L, Tornqvist H and Robinson S.D (2005). Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112: 3930-3936.
Muller J, Huaux F and Moreau N (2005). Respiratory toxicity of multi-wall carbon nanotubes. Toxicol Appl Pharmacol 207: 221-231.
Nel A, Xia T and Madler L (2006). Toxic potential of materials at the nanolevel. Science 311: 622-627.
O’Neal D.P, Hirsch L.R and Halas N.J (2004). Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett 209:171-176.
Oberdörster G, Maynard A and Donaldson K (2005). Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Fibre Toxicol 2: 8-12.
Pope C.A, Burnett RT and Thurston GD (2004). Cardiovascular mortality and long term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 109: 71-77.
Radomski, A. Jurasz, P.; Alonso-Escolano, D (2005). Nanoparticle-induced platelet aggregation and vascular thrombosis. Br J Pharmacol 146: 882–893.
Ravi Kumar M.N, Gameti M and Mohapatra S.S (2004). Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo. J Nanosci Nanotechnol 4: 876-881.
Rejeski D and Lekas D (2008). Nanotechnology field observations: scouting the new industrial west. Journal of Cleaner Prod 16: 1014-1017.
Sayes C.M, Liang F and Hudson J.L (2006). Functionalization density dependence of single-walled carbon nanotubes cytotoxicity in vitro. Toxicol Lett 161: 135-142.
Schins RPF, Lightbody JH and Borm PJA (2004). Inflammatory effects of coarse and fine particulate matter in relation to chemical and biological constituents. Toxicol Appl Pharmacol 195: 1-11.
Shenoy D, Fu W and Li J (2006). Surface functionalization of gold nanoparticles using hetero-bifunctional poly(ethylene glycol) spacer for intracellular tracking and delivery. Int J Nanomedicine 1: 51-57.
Shvedova A.A, Castranova V and Kisin ER (2003). Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environm Health Part A 66: 1909-1926.
Svenson S and Tomalia DA (2005). Dendrimers in biomedical applications – reflections on the field. Adv Drug Del Rev 57: 2106–2129.
Takenaka S, Karge E and Kreyling WG (2006). Distribution pattern of inhaled ultrafine gold nanoparticles in the rat lung. Inhalation Toxicol 18: 733-740.
The Royal Society and the Royal Academy of Engineering (2004). Nanoscience and nanotechnologies: opportunities and uncertainties. London, UK.
Vasir JK, Reddy MK and Ladhasetwar VD (2005). Nanosystems in drug targeting: Opportunities and challenges. Current Nanoscience 1: 47-64.
Warheit DB, Laurence BR and Reed KL (2004). Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol Sci 77: 117-125.
Yamakoshi Y, Umezawa N and Ryu A (2003). Active oxygen species generated from photo-excited fullerene (C-60) as potential medicines: O2− versus 1O2 . J Am Chem Soc 125: 12803-12809.
