Formulation and Evaluation of Nanosuspension Formulation for Drug Delivery of Simvastatin
DOI:
https://doi.org/10.37285/ijpsn.2014.7.4.7Abstract
Poor water solubility and slow dissolution rate are issues drug content and polydispersity index. The obtained for the majority of upcoming and existing biologically results showed that particle size (nm) and rate of active compounds. Simvastatin is poorly water-soluble dissolution has been improved when nanosuspension drug and its bioavailability is very low from its crystalline prepared with the higher concentration of PVPK-30 and form. The purpose of the present investigation was to Poloxamer-188 and lower concentration of SLS. The increase the solubility and dissolution rate of simvastatin by particle size and zeta potential of optimized formulation the preparation of nanosuspension by Emulsification was found to be 258.3 nm and 23.43. The rate of Solvent Diffusion Method at laboratory scale. Prepared dissolution of the optimized nanosuspension was nanosuspension was evaluated for its particle size and enhanced (90.02% in 60min), relative to plain simvastatin in vitro dissolution study and characterized by zeta (21% in 60 min), mainly due to the formation of nanosized potential, differential scanning calorimetry (DSC) and particles. These results indicate the suitability of 23 factorial X-Ray diffractometry (XRD), Motic digital microscopy, design for preparation of simvastatin loaded nanosus- entrapment efficiency, total drug content, saturated pension significantly improved in vitro dissolution rate, solubility study and in vivo study. A 23 factorial design was and thus possibly enhance fast onset of therapeutic drug employed to study the effect of independent variables, effect. In vivo study shows increase in bioavailability in amount of SLS (X1), amount of PVPK-30 (X2) and nanosuspension formulation than the plain simvastatin Poloxamer-188 (X3) and dependent variables are Total drug.
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Keywords:
Simvastatin, Nanosuspension, Emulsification Solvent Diffusion, Dissolution, Particle Size, Factorial design
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Amit Chaudhary et al., (2012). Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education & Research 2(1): 32-67.
Amit J. Raval et al., (2011). Preparation and characterization of nanoparticles for solubility and dissolution rate enhancement of meloxicam. Intl. R. J. of Pharmaceuticals 01: 42-49.
Ana M.C, Bruno Gander MM (2010). Miconazole nanosuspensions: influence of formulation variables on particle size reduction and physical stability. International Journal of Pharmaceutics. 396: 210-218.
Anilkumar J. Shinde et al., (2011). Formulation and Optimization of Biodegradable Polylactic-coglycolic acid Nanoparticles of Simvastatin using Factorial design. Der Pharmacia Sinica 2(5): 198-209.
Ankit Vaghela et al., (2012). Nanosuspension Technology. International Journal of Universal Pharmacy and Life Sciences. 2(2): 306-317.
Ashish Kumar Verma et al., (2012). Nanosuspensions: Advantages and Disadvantages. Indian Journal of Novel Drug Delivery. 4(3): 179-188.
Ashok Kumar Suthar et al., (2011). Enhancement of dissolution of poorly water soluble raloxifene hydrochloride by preparing nanoparticles. Journal of Advanced Pharmacy Education & Research 2: 189-194.
Athul P.V (2013). Preparation And Characterization Of Simvastatin Nanosuspension By Homogenization Method. International Journal of Pharm Tech Research 5(1): 193-197.
Battula S. R et al., (2012). Nano Fabricated Drug Delivery Devises. International Journal Of Pharmacy & Technology 4(1): 1974-1986.
Bernard V. Eerdenbrugh, F Humbeeck J (2008). Drying of crystalline drug nanosuspensions The importance of surface hydrophobicity on dissolution behavior upon redispersion. European Journal of Pharmaceutical Sciences 35: 127-135.
Bhargavi R A (2011). Technical Review Of Nanosuspensions. International Journal Of Pharmacy & Technology 3(3): 1503-1511.
B. P. Patel et al., (2012). A Review On Techniques Which Are Useful For Solubility Enhancement Of Poorly Water Soluble Drugs. International Journal For Research In Management And Pharmacy 1: 56-70.
CH. Prabhakar et al., (2011). A Review On Nanosuspensions In Drug Delivery. International Journal Of Pharma And Bio Sciences 2: 549-558.
Chaudhari Bharat et al. (2013). Preparation and Evaluation of Nanosuspension of Poorly Soluble Drug Albendazole.Journal of Drug Discovery and Therapeutics. 1(1): 37-42.
Chetan Detroja et al., (2011). Enhanced antihypertensive activity of candesartan cilexetil nanosuspension: formulation, characterization and pharmacodynamic study. Sci Pharm 79: 635-651.
C. Jacobs et al., (2000). Nanosuspensions as a new approach for the formulation for the poorly soluble drug tarazepide. International Journal of Pharmaceutics 196: 161-164.
Colin W. Pouton (2006). Formulation of poorly water-soluble drugs for oral administration: Physicochemical and physiological issues and the lipid formulation classification system. European Journal Of Pharmaceutical Sciences 29: 278-287.
Cornelia M. Keck et al., (2006). Drug nanocrystals of poorly soluble drugs produced by high pressure homogenization. European Journal of Pharmaceutics and Biopharmaceutics 62: 3-16.
Daisy Sharma et al., (2009). Solubility Enhancement–Eminent Role in Poorly Soluble Drugs. Research J. Pharm. and Tech 2(2): 220-224.
Debjit Bhowmik et al., (2012). Nanosuspension -A Novel Approaches In Drug Delivery System. The Pharma Innovation – Journal. 1(12): 50-63.
Dhaval J. Patel et al., (2010). Optimization of Formulation Parameters on Famotidine Nanosuspension Using Factorial Design and the Desirability Function. International Journal of Pharm Tech Research 2: 155-161.
Dineshkumar B et al., (2013). Nanosuspension Technology in Drug Delivery System. Nanoscience and Nanotechnology. An International Journal 3(1): 1-3.
Esmaeili F et al., (2008). Preparation and characterization of estradiol-loaded PLGA nanoparticles using homogenization-solvent diffusion method. DARU 16(4): 196-202.
Ezeddin Kolaib et al., (2013). Nanodispersions Platform for Solubility Improvement. International Journal of Research in Pharmaceutical and Biomedical Sciences 4(2): 636-643.
G. Praveen kumar et al., (2011). Nanosuspensions: The Solution to Deliver Hydrophobic Drugs. International Journal of Drug Delivery 3: 546-557.
Geeta Vikram Yadav et al., (2012). Nanosuspension: A Promising Drug Delivery System. Pharmacophore 3(5): 217-243.
Ghulam Murtaza et al., (2012). Solubility Enhancement of Simvastatin: A Review. Acta Poloniae Pharmaceutica- Drug Research 69(4): 581-590.
Glyceride Lipids: Formulation, Characterization, in vitro Drug Release, and Stability Evaluation. AAPS Pharm Sci Tech. 6(2): 158-166.
Hanafy A, H. Spahn-Langguth, G. Vergnault and P. Grenier (2007). Pharmacokinetic evaluation of oral fenofibrate nanosuspensions and SLN in comparison to conventional suspensions of micronized drug. Advanced Drug Delivery Reviews 59: 419-426.
H banavath et al., (2010). Nanosuspension: an attempt to enhance bioavailability of poorly soluble drugs. International Journal of Pharmaceutical Science and Research 1(9): 1-11.
Hany S.M. Ali et al., (2009). Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics 375: 107-113.
Harivardhan L, Reddy and R Murthy S.R (2005). Etoposide-loaded nanoparticles made from glyceride lipids: Formulation, characterization, in vitro drug release, and stability evaluation. AAPS Pharm Sci Tech. 6(2): E158–E166.
Jiraporn chingunpituk et al., (2007). Nanosuspension Technology for Drug Delivery.Walailak J Sci & Tech 4(2): 139-153.
Jayakumar. C et al., (2012). Solubility Enhancement Of Theophylline Drug Using Different Solubilization Techniques. International Journal Of Pharmaceutical And Clinical Science 2(1): 7-10.
J. Hecq a et al., (2006). Preparation and in vitro/in vivo evaluation of nano-sized crystals for dissolution rate enhancement of ucb-35440-3, a highly dosed poorly water-soluble weak base. European Journal of Pharmaceutics and Biopharmaceutics. 64: 360-368.
Joseph W, Andrew B Khare A. Chaubal M, Pavlos P, Barrett R, James K and Ning J (2008). Suspensions for intravenous (IV) injection: A review of development, preclinical and clinical aspects. Advanced Drug Delivery Reviews 60: 939-954.
Ji-Yeun Choi, Chul Ho Park and Jonghwi Lee (2008). Effect of Polymer Molecular Weight on Nanocomminution of Poorly Soluble Drug Nanoparticles. Drug Development and Industrial Pharmacy 34: 1209-1218.
Kalle S, Sara F, Holländer P, Urban S, Jennie de V (2007). A formulation comparison, using a solution and different nanosuspensions of a poorly soluble compound. European Journal of Pharmaceutics and Biopharmaceutics 67: 540–547.
Kalpesh S. Wagh et al., (2011). Nanosuspension-A New Approach Of Bioavailability Enhancement. International Journal Of Pharmaceutical Sciences Review And Research 8: 61-65.
Kapadiya Nidhi et al., (2011). Hydrotropy: A Promising Tool For Solubility Enhancement: A Review. International Journal Of Drug Development & Research 3: 26-33.
Kassem M.A, Abdel Rahmanb, A.A. Ghorab M.M, Ahmed M.B, and Khalil R.M (2007). Nanosuspension as an ophthalmic delivery system for certain glucocorticoid drugs. Int J Pharm 340: 126-133.
Katy M and Shlomo M (2009). Formation of simvastatin nanoparticles from microemulsion. Nanomedicine: Nano-technology, Biology, and Medicine 5: 274-281.
Kipp J.E (2004). The role of solid nanoparticle technology in the Parenteral delivery of poorly water-soluble drugs. International Journal of Pharmaceutics 284: 109-122.
Koteshwara K.B et al., (2011). Nanosuspension: A Novel Drug Delivery Approach. IJRAP 2(1): 162-165.
La F. Pini E, Angioni, G. MancM.L. Perricci and J. Sinico C (2011). Nanocrystals as tool to improve piroxicam dissolution rate in novel orally disintegrating tablets. European Journal of Pharmaceutics and Biopharmaceutics 79: 552-558.
Leena P, Johanna A, Samuli H, Milja Karjalainen, Hirvonen J (2004). Improved Entrapment Efficiency of Hydrophilic Drug Substance During Nanoprecipitation of Poly(l)lactide Nanoparticles. AAPS Pharm Sci Tech 5(1): 1-6.
Lei G Zhang, M Chen Zheng and T. Wang S (2007). Preparation and Characterization of an Oridonin Nanosuspension for Solubility and Dissolution Velocity Enhancement. Drug Development and Industrial Pharmacy 33: 1332-1339.
Mahendra Nakarani et al., (2010). Cyclosporine A-Nanosuspension: Formulation, Characterization and in vivo Comparison with a Marketed Formulation. Sci Pharm 78: 345–361.
Meenakshi Shukla et al., (2010). Enhanced Solubility Study Of Glipizide Using Different Solubilization Techniques. International Journal Of Pharmacy And Pharmaceutical Sciences 2: 46-48.
Meetali Mudgil et al., (2012). Nanotechnology: A New Approach For Ocular Drug Delivery System. International Journal Of Pharmacy And Pharmaceutical Sciences 4(2): 105-112.
Mishra B et al., (2010). Investigation of formulation variables affecting the properties of lamotrigine nanosuspension using fractional factorial design. DARU 18(1): 1-8.
Mitesh Patel et al., (2011). Nanosuspension: A Novel Approch For Drug Delivery System. JPSBR 1: 1-10.
Mohanty Sivasankar et al., (2010). Role of Nanoparticles in Drug Delivery System. International Journal of Research in Pharmaceutical and Biomedical Sciences 1(2): 41-66.
Mukesh S Patil et al., (2011). Preparation And Optimization Of Simvastatin Nanoparticle For Solubility Enhancement And in- vivo Study. International Journal of Pharma Research and Development – Online 2: 219-226.
N.Arunkumar et al., (2009). Preparation and solid state characterization of atorvastatin nanosuspensions for enhanced solubility and dissolution. International Journal of Pharm Tech Research 1: 1725-1730.
Nagaraju P et al., (2010). Nanosuspension: A Promising Drug Dilivery System. International Journal of Pharmaceutical Sciences and Nanotechnology 2(4): 679-684.
Nagare S.K et al., (2012). A review on Nanosuspension: An innovative acceptable approach in novel delivery system. Universal Journal of Pharmacy 1(1): 19-31.
Nakarani Metal (2010). Itraconazol Nanosuspension For Oral Delivery: Formulation, Charactrization and In vitro comparison with Marketed Formulation. DARU 18(2): 84-90.
Nanosuspension as an ophthalmic delivery system for certain glucocorticoid drugs. International Journal of Pharmaceutics. 340: 126-133.
Nekkanti V. Pillai R Venkateshwarlu V and Harisudhan T. (2009). Development and characterization of solid oral dosage form incorporating candesartan nanoparticles. Pharmaceutical Development and Technology 14(3): 290-298.
O. Kayser (2000). Nanosuspensions for the formulation of aphidicolin toimprove drug targeting effects against Leishmania infected macrophages. International Journal of Pharmaceutics 196: 253-256.
P. Jorvekar et al., (2012). Formulation Development Of Aceclofenac Loaded Nanosuspension by Three Square (32) Factorial Design. International Journal Of Pharmaceutical Sciences and Nanotechnology 4: 1575-1582.
Patel Anita P et al., (2011). A review on drug nanocrystal a carrier free drug delivery. IJRAP 2(2): 448-458.
Panchaxari Dandagi et al., (2009). Polymeric ocular nanosuspension for controlled release of acyclovir: in vitro release and ocular distribution. Iranian Journal of Pharmaceutical Research 8: 79-86.
Patil Sonal A et al., (2011). Nanosuspension: At A Glance. International Journal Of Pharmaceutical Science 3(1): 947-960.
Patrice Tewa-Tagne, St´ephanie Brianc¸onHatem Fessi (2007). Preparation of redispersible dry nanocapsules by means of spray-drying: Development and characterization. European Journal Of Pharmaceutical Sciences 30: 124-135.
Paun J.S et al., (2012). Nanosuspension: An Emerging Trend for Bioavailability Enhancement of Poorly Soluble Drugs. Asian J. Pharm. Tech 2(4): 157-168.
Pintu Kumar De et al., (2012). Nanosuspensions: Potent vehicles for drug delivery and bioavailability enhancement of lipophilic drugs. Journal of Pharmacy Research 5(3): 1548-1554.
Prabhat R. Mishra, Loaye Al Shaal, Rainer H. Müller, Cornelia M. Keck (2009). Production and characterization of Hesperetin nanosuspensions for dermal delivery. International
Journal of Pharmaceutics 371: 182-189.
Prasanna Lakshmi et al., (2010). Nanosuspension Technology: A Review. International Journal Of Pharmacy And Pharmaceutical Sciences 2(4): 35-40.
Prasanta Dey et al., (2012). Nanotechnology For The Delivery Of Poorly Water Soluble Drugs. The Global Journal Of Pharmaceutical Research 1(3): 225-250.
Puckhraj Chhaprel et al., (2012). Solubility Enhancement Of Poorly Water Soluble Drug Using Spray Drying Technique. International Journal Of Pharmaceutical Studies And Research 3: 01-05.
R. Ambrus et al., (2009). Investigation of preparation parameters to improve the dissolution of poorly water-soluble meloxicam. International Journal of Pharmaceutics 381: 153-159.
Rajalakshmi R et al., (2012). Design and characterization of valsartan nanosuspension. Inter. J. of Pharmacotherapy 2: 70-81.
Rainer H. Muller and Katrin Peters (1998). Nanosuspensions for the formulation of poorly soluble drugs. Preparation by a size-reduction technique. International Journal of Pharmaceutics. 160: 229-237.
Ranjita Shegokar et al., (2010). Nanocrystals: Industrially feasible multifunctional formulation technology for poorly soluble actives. International Journal of Pharmaceutics 399: 129-139.
Sanjay Bansal et al., (2012). Nanocrystals: Current Strategies and Trends. International Journal of Research in Pharmaceutical and Biomedical Sciences 3(1): 406-419.
Santhosh Kumar K et al., (2010). Solubility Enhancement Of A Drug By Liquisolid Technique. International Journal Of Pharma And Bio Sciences 1: 1-5.
Satish K. Patil et al., (2011). Strategies For Solubility Enhancement Of Poorly Soluble Drugs. International Journal Of Pharmaceutical Sciences Review And Research 8: 74-80.
Shailesh Soni et al., (2012). Nanosuspension: An Approach to Enhance Solubility of Drugs. IJPI’s Journal of Pharmaceutics and Cosmetology 2(9): 50-63.
Shelke P.V et al., (2012). A Review On Formulation And Evaluation Of Nanosuspension. International Journal Of Universal Pharmacy And Life Sciences 2(3): 516-524.
Shivanand Pandey et al., (2010). Nanosuspension: Formulation, Charcterization And Evaluation. International Journal Of Pharma And Bio Sciences 1(2): 1-10.
Sonia Dhiman et al., (2011). Nanosuspension: a recent approach for nano drug delivery system. International journal of current pharmaceutical research 3: 96-101.
Srinivasa Rao K et al., (2011). An Overview of Statins as Hypolipidemic Drugs. International Journal of Pharmaceutical Sciences and Drug Research 3(3): 178-183.
Suman katteboinaa et al., (2009). Drug nanocrystals: A novel formulation approach for poorly Soluble drugs. International journal of pharmtech research 1(3): 682-694.
Sonam Jain et al., (2012). Solubility Enhancement By Solvent Deposition Technique: An Overview. Asian Journal Of Pharmaceutical And Clinical Research 5(4): 15-19.
Suzanne M. D'Addio, Robert K. Prud'homme (2011). Controlling drug nanoparticle formation by rapid precipitation. Advanced Drug Delivery Reviews 63: 417-426.
Toshi Chaurasia et al., (2012). A Review on Nanosuspensions promising Drug Delivery Strategy. Current Pharma Research. 3(1): 764-776.
T. Venkatesh et al., (2011). Nanosuspensions: Ideal Approach for the Drug Delivery of Poorly Water Soluble Drugs. Der Pharmacia Lettre 3(2): 203-213.
Varun Raj Vemula et al., (2010). Solubility Enhancement Techniques Review Article. International Journal of Pharmaceutical Sciences Review and Research 5: 41-51.
Vermaa S, Yan Gokhaleb LR and Diane J. Burgess (2009). Quality by design approach to understand the process of nanosuspension preparation. International Journal of Pharmaceutics 377: 185-198.
Vidyavathi maravajhala et al., (2012). Nanotechnology in development of drug delivery system. International Journal of Pharmaceutical Science and Research 3(1): 84-96.
V. B. Patravale et al., (2004). Nanosuspensions: a promising drug delivery strategy. Journal of Pharmacy and Pharmacoloy 56: 827-840.
Vikas jain et al., (2011). Development and characterization of Mucoadhesive Nanosuspension of ciprofloxacin. Acta poloniae pharmaceutica and drug research 68(2): 273-278.
Vishvajit A. Kamble et al., (2010). Nanosuspension A Novel Drug Delivery System. International Journal Of Pharma And Bio Sciences 1: 352-360.
Wei Li et al., (2011). Preparation and in vitro/in vivo evaluation of revaprazan hydrochloride nanosuspension. International Journal Of Pharmaceutics 408: 157-162.
Xiaohui Pu et al., (2009). Formulation of Nanosuspensions as a New Approach for the Delivery of Poorly Soluble Drugs. Current Nanoscience 5: 417-427.
Xue M.Li, Li Gu, YuanLong Xu, YongLu Wang (2009). Preparation of fenofibrate nanosuspension and study of its pharmacokinetic behavior in rats. Drug Development and Industrial Pharmacy 35(7): 827-833.
Yogesh S. Thorat et al., (2011). Solubility Enhancement Techniques: A Review On Conventional And Novel Approaches. IJPSR 2(10): 2501-2513.
