Formulation and Evaluation of Self-Nanoemulsifying Drug Delivery System of Naproxen
DOI:
https://doi.org/10.37285/ijpsn.2015.8.1.3Abstract
Self-emulsifying drug delivery systems (SEDDS) possess unparalleled potential in improving oral bioavailability of poorly water-soluble drugs. Following their oral administration, these systems rapidly disperse in gastrointestinal fluids, yielding micro or nanoemulsions containing the solubilized drug. The objective of the present work was to formulate a self nanoemulsifying drug delivery system (SNEDDS) for naproxen. Naproxen SNEDDS were formulated using Labrafac PG (Oil), Span 80 (Surfactant) and propylene glycol (Co surfactant). The developed SNEDDS were evaluated for turbidimetry, droplet size analysis, zeta potential, refractive index, viscosity, drug content and in vitro diffusion profiles. All formulations of naproxen SNEDDS showed globule size in nanometric range, good stability with no phase separation and rapidly formed clear emulsion. All formulations showed more than 95% of drug release at the end of 60 min. The SEDDS showed improved dissolution rate compared to pure naproxen. Anti-inflammatory studies were conducted in Wistar strain male albino rats and ibuprofen SNEDDS showed more significant activity than the pure drug. The study illustrated the potential of naproxen SNEDDS for oral administration and its biopharmaceutical performance.
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Keywords:
SNEDDS, naproxen, Anti-inflammatory studies, turbidimetry
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References
Atef E and Belmonte AA (2008). Formulation and In Vitro and In Vivo Characterization of a Phenytoin Self-Emulsifying Drug Delivery System (SEDDS). Eur J Pharm Sci. 35(4): 257-263.
Balakrishnan P, Lee BJ, Oh DH, Kim JO, Lee YI and Kim DD (2009). Enhanced Oral Bioavailability of Coenzyme Q10 by Self-Emulsifying Drug Delivery Systems. Int J Pharm. 374(1-2): 66-72.
Bari HC, Doijad RC, More HN and Disouza JI (2011). Design and Optimization of Chlordiazepoxide Solid Self-Microemulsifying Drug Delivery System. J Pharma Res. 4(2): 369-372.
Bhikshapathi D, Madhukar P, Kumar BP and Kumar GA (2013). Formulation and Characterization of Pioglitazone Hcl Self Emulsifying Drug Delivery System. Der Pharmacia Lettre. 5(2): 292-305.
Deshmukh A and Kulkarni S (2012). Novel Self Micro-Emulsifying Drug Delivery Systems (SMEDDS) of Efavirenz. J Chem Pharma Res. 4(8): 3914-3919.
Kamble VA, Jagdale DM and Kadam VJ (2010). Self Micro Emulsifying Drug Delivery System. Int J Pharm and Bio Sci. 1(2): 1-9.
Kallakunta VR, Bandari S, Jukanti R and Veerareddy PR (2012). Oral Self Emulsifying Powder of Lercanidipine Hydrochloride: Formulation and Evaluation. Powder Technol. 221: 375-382.
Kassem AA, Marzouk MA, Ammar AA and Elosaily GH (2010). Preparation and In Vitro Evaluation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) containing Clotrimazole. Drug Discov Thera. 4(5): 373-379.
Lichtenberger M, Romero JJ, Dial EJ and Moore JE (2009). Naproxen-PC: A GI Safe and Highly Effective Anti-Inflammatory. Inflammopharmacology. 17(1): 1-5.
Lipinski C (2002). Poor Aqueous Solubility: an Industry wide problem in Drug Discovery. Am Pharm Rev. 5: 82-88.
Maghsoodi M, Hassan-Zadeh D and Bazegar-Jalali M (2007). Improved Compaction and Packing Properties of Naproxen Agglomerated Crystals Obtained by Spherical Crystallization Technique. Drug Dev Ind Pharm. 33(11): 1216-1224.
Mudit D, Parthasarathi KP, Sojan J, Ashwini KG and Akash J (2010). Formulation and Evaluation of Positively Charged Self Emulsifying Drug Delivery System Containing a NSAID. Int J Ph Sci. 2(3): 792-803.
Nastasa V, Samaras K, Andrei IR, Pascu ML and Karapantsios T (2011). Study of the Formation of Micro and Nano-Droplets Containing Immiscible Solutions. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 382(1-3): 246-250.
Ohara T, Kitamura S and Kitagawa T (2005). Dissolution Mechanism of Poorly Water –Soluble Drug from Extended Release Solid Dispersion System with Ethyl Cellulose and Hydroxypropylmethylcellulose. Int J Pharm. 302(1-2): 95-102.
Patel SN, Patel DM, Patel CN, Patel TD, Prajapati PH and Parikh BN (2010). Self Emulsifying Drug Delivery System. J Global Pharma Tech. 2(2): 29-37.
Porwal P, Bhargava S, Bhaduria RS, Shukla SS and Daharwal SJ (2012). Formulation and In-Vitro Characterization of Self Emulsifying Drug Delivery System of Cisapride. Adv Res Pharma Bio. 2(4): 324-328.
Rao CM, Ramesh KV, Biary KL and Kulkarni DR (1990). Zinc Complexes of Nsaids Abolish Gastric Ulceration Propensity of Parent Drugs. Indian Drugs. 28(2): 64- 67.
Shafiq-un-Nabi S, Shakeel F, Talegaonkar S, Ali J, Baboota S and Ahuja A (2007). Formulation Development and Optimization Using Nanoemulsion Technique: A technical note. AAPS Pharm Sci Tech. 8(2): E1-E6.
Yalkowsky S (1981). Technique of Solubilization of Drugs. 1st ed. New York: Marcher Dekker.
