Pharmacological Evaluation of Anti-ulcer Activity of Caesalpinia crista in Rats
DOI:
https://doi.org/10.37285/ijpsn.2017.10.4.4Abstract
In present study, we evaluated the antiulcer activity of the herbal preparation of Caesalpinia crista in rat models. Experimental animals were divided into four groups. Rats of group I (disease control) treated with normal saline only, group II (standard group) treated with Omeprazole (2 mg/ kg; p.o.), group III and IV served as test groups and were treated with Caesalpinia crista extract (CE) in the dose of 250 mg/ kg and 500 mg/ kg orally respectively. Peptic ulcer was induced by ligating the pyloric portion of rat stomach and was done 45 min after the respective treatment. After 4 hour of pylorus ligation, rats were sacrificed. Parameters like ulcer index, percent ulcer protection, total and free acidity were estimated for evaluation of anti-ulcer activity. Histopathological evaluation was also performed. The aqueous extract of Caesalpinia crista seeds reduced the volume of gastric juice, free acidity, total acidity and ulcer index. It increased the pH of the gastric acid. Histopathology of the rat stomach revealed the presence of lesions and infiltration of inflammatory cells in control group. Moreover, animals treated with test drug and standard drug did not reveal any microscopic lesions. These findings suggest that Caesalpinia crista seeds may have anti-secretory and anti-ulcer activity and may be helpful for ulcer therapy.
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Keywords:
Peptic ulcer, Pylorus ligation, Omeprazole, C Crista, Rat
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Published
2017-07-31
How to Cite
1.
Patel K, Patel B, Patel A, Shah S. Pharmacological Evaluation of Anti-ulcer Activity of Caesalpinia crista in Rats. Scopus Indexed [Internet]. 2017 Jul. 31 [cited 2024 Dec. 22];10(4):3772-9. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/854
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Research Articles
References
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Billah MM, Islam R, hajerakhatun, Parvin S, Islam E Islam SM and Alimia A (2013). Antibacterial, antidiarrheal and cytotoxic activities of methanol extract and its fraction of Caesalpinia bonducellaRoxb. leaves. BMC complementary and alternative medicine 13: 101.
Bodakhe SH, Agrawal A, Agrawal A, Shinde N and Namdeo KP (2011). Anticancer Study on alcoholic extract of Caesalpinia crista root bark extract. J. of Pharmaceutical Research and opinion1. 126.
ChitraV, Madhuri SD and Rajlakshmi V (2013). Evaluation of anti-ulcer activity of alcoholic extract of GarugapinnataRoxb. Leaves in experimental animal models. Int. J. Tech. Res 5: 991.
Dharmani P and Patil G (2006). Exploring Indian medicinal plants for antiulcer activity. Indian J Pharmacol. 38(2): 95-99.
DuttaA, Lal N, Naza M, Ghosh A and Verma R (2014). Ethnological and Ethno-medicinal importance of Aeglemarmelos (L.) corr. (Bael) among indigenous people of India. American journal of ethnomedicine. 1(5): 290-312.
Gadekar P, Singour PK, Chaurasiya PK, Pawar RS and Patil UK (2010). A potential of some medicinal plants as an anti-ulcer agents. Pharmacognosy rev. 4(8): 136-146.
Gaur R.L., Sahoo MK, Rastogi S, Kulshreshtha DK and Murthee PK (2008). Antifilarial activity of Caesalpinia bonducella against experimental infections. Indian journal of medicinal research. 128(1): 65-70.
Gupta N, Sharma S, Agrawal M, Mohmmad M, Chauhan P, Anwer T and khan G. (2013). Antidiabetic activity of seed extract of Caesalpinia crista Linn. In experimental animals. African journal of pharmacy and pharmacology. 7(26): 1808-1813.
Herfindal ET, Helms Ra, Quam DJ and Gourley DR (2006). Textbook of therapeutics drug and discovery management. Lippincott Williams & wilikins.
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Jainu M, Vijaymohan K and Shyamaladevi CS (2006). Gastro protective effect of cissusquadrangularis extract in rats with experimentally induced ulcer. Indian J Med Res. 123(6): 799-806.
Jaykrishnan BM, Nagaraja P and Hashim KM (2014). In vitro antioxidant studies and phytochemical screening on the seeds of Caesalpinia bonduc.European journal of Experimental Biology. 4(4): 47-51.
Kalauni SK, Awale S, Tezuka Y, Banskota AH, Asih P, Syafruddin D and Kadota S (2006). Antimalarial activity of Cassane- and Norcassane- Type Diterpenes from Caesalpinia crista and structure activity relationship. Biol. Pharm. Bull. 29(5): 1050-2
Kaur D, Rana A, Sharma N and Kumar S (2012). Herbal drugs with anti-ulcer activity. Journal of applied pharmaceutical science. 2(3): 160-165.
Kokate CK, Purohit AP and Gokhale SB (1990). Pharmacognosy Nirali Prakashan, Pune.
Longo DL, Kasper DL, Fauci AS, Hauser SL, Raunwald E and Jameson J (2005). Harrison’s principles of internal medicine. McGraw hill medical publishing division.
Madhulatha CH, Kalyani G, Shushma GS, Subramanian N and Devi A (2013). Anti-ulcer activity of Pisonia aculeate on pylorus ligation induced gastric ulcer in rats. International journal of pharmacy and life science. 4(3): 2440-2443.
Mandal S, Hazra B, Sarkar R, Biswas S and Mandal N (2009). Assessment of the antioxidant and reactive oxygen species scavenging activity of methanolic extract of Caesalpinia crista leaf. Evidence-based complementary and alternative medicine. 1
Md. Mahfoozurrahman, Asif M and Kabir H (2012). Analgesic and anti-inflammatory activities of aqua form of Caesalpinia bonducella seed in rats. Int. J. of pharmaceutical sciences and research. 3(11): 4235.
Merai A and Jadhav A (2014). Antiulcer activity of Carissa carandas using root extract in albino rats.World journal of pharmacy and pharmaceutical science. 3: 1314.
Mirje M and Uz zaman S (2014). Evaluation of antiulcer activity of ocimum sanctum(tulsi) in indomethacin nduced gastric ulcer in albino rats.Int. J. Lifesc. Bt & Pharma. Res. 3: 274.
Panda V and Sonkamble M (2012). Anti -ulcer activity of Ipomoeabatatas tubers (sweet potato). Functional foods in health and Disease. 2: 48.
Patil KS (2005). Wound healing activity of the seed kernels of Caesalpinia crista Linn. Journal of Natural Remedies. 5(1): 26.
Reddy VP, Sudheshna G, Afsar SK, Saran S, Kumar S, Raja ram C and Reddy KR (2012). Evaluation of anti-ulcer activity of citrulluscolocynthis fruit against pylorus ligation induced ulcers in male wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences. 4: 446.
Sabrin F, Hasan MN, Islam KD, Rahman MM and Billah MM (2011). Investigation on antimicrobial activities of the two selected shrub from the sundarbans (Clerodendruminerme and Caesalpinia crista). J. Innov. Dev. Strategy. 5(2): 62-69.
Shah SJ and Patel JR (2012). Antiulcer activity of lucer against experimentally induced gastric ulcer in rats. Phisiol. Pharmacol. 33(2): 314-316.
Sharma G, Dubey SK, Sati N and Sanadya J (2011). Ulcer healing potential of Aeglemarmelos fruit seed. Asian journal of pharmacy and life science. 1(2): 172.
Tripathi KK, Bhowmik D and Sampathkumar KP (2010). Recent trends of treatment and medication peptic ulcerative disorder. International journal of pharmatech research. 2(1): 970-980.
Billah MM, Islam R, hajerakhatun, Parvin S, Islam E Islam SM and Alimia A (2013). Antibacterial, antidiarrheal and cytotoxic activities of methanol extract and its fraction of Caesalpinia bonducellaRoxb. leaves. BMC complementary and alternative medicine 13: 101.
Bodakhe SH, Agrawal A, Agrawal A, Shinde N and Namdeo KP (2011). Anticancer Study on alcoholic extract of Caesalpinia crista root bark extract. J. of Pharmaceutical Research and opinion1. 126.
ChitraV, Madhuri SD and Rajlakshmi V (2013). Evaluation of anti-ulcer activity of alcoholic extract of GarugapinnataRoxb. Leaves in experimental animal models. Int. J. Tech. Res 5: 991.
Dharmani P and Patil G (2006). Exploring Indian medicinal plants for antiulcer activity. Indian J Pharmacol. 38(2): 95-99.
DuttaA, Lal N, Naza M, Ghosh A and Verma R (2014). Ethnological and Ethno-medicinal importance of Aeglemarmelos (L.) corr. (Bael) among indigenous people of India. American journal of ethnomedicine. 1(5): 290-312.
Gadekar P, Singour PK, Chaurasiya PK, Pawar RS and Patil UK (2010). A potential of some medicinal plants as an anti-ulcer agents. Pharmacognosy rev. 4(8): 136-146.
Gaur R.L., Sahoo MK, Rastogi S, Kulshreshtha DK and Murthee PK (2008). Antifilarial activity of Caesalpinia bonducella against experimental infections. Indian journal of medicinal research. 128(1): 65-70.
Gupta N, Sharma S, Agrawal M, Mohmmad M, Chauhan P, Anwer T and khan G. (2013). Antidiabetic activity of seed extract of Caesalpinia crista Linn. In experimental animals. African journal of pharmacy and pharmacology. 7(26): 1808-1813.
Herfindal ET, Helms Ra, Quam DJ and Gourley DR (2006). Textbook of therapeutics drug and discovery management. Lippincott Williams & wilikins.
Howland RD and Mycek MJ (2006). Lippincott’s illustrated reviews Pharmacology. B.I. Publication Pvt.Limited.
Jainu M, Vijaymohan K and Shyamaladevi CS (2006). Gastro protective effect of cissusquadrangularis extract in rats with experimentally induced ulcer. Indian J Med Res. 123(6): 799-806.
Jaykrishnan BM, Nagaraja P and Hashim KM (2014). In vitro antioxidant studies and phytochemical screening on the seeds of Caesalpinia bonduc.European journal of Experimental Biology. 4(4): 47-51.
Kalauni SK, Awale S, Tezuka Y, Banskota AH, Asih P, Syafruddin D and Kadota S (2006). Antimalarial activity of Cassane- and Norcassane- Type Diterpenes from Caesalpinia crista and structure activity relationship. Biol. Pharm. Bull. 29(5): 1050-2
Kaur D, Rana A, Sharma N and Kumar S (2012). Herbal drugs with anti-ulcer activity. Journal of applied pharmaceutical science. 2(3): 160-165.
Kokate CK, Purohit AP and Gokhale SB (1990). Pharmacognosy Nirali Prakashan, Pune.
Longo DL, Kasper DL, Fauci AS, Hauser SL, Raunwald E and Jameson J (2005). Harrison’s principles of internal medicine. McGraw hill medical publishing division.
Madhulatha CH, Kalyani G, Shushma GS, Subramanian N and Devi A (2013). Anti-ulcer activity of Pisonia aculeate on pylorus ligation induced gastric ulcer in rats. International journal of pharmacy and life science. 4(3): 2440-2443.
Mandal S, Hazra B, Sarkar R, Biswas S and Mandal N (2009). Assessment of the antioxidant and reactive oxygen species scavenging activity of methanolic extract of Caesalpinia crista leaf. Evidence-based complementary and alternative medicine. 1
Md. Mahfoozurrahman, Asif M and Kabir H (2012). Analgesic and anti-inflammatory activities of aqua form of Caesalpinia bonducella seed in rats. Int. J. of pharmaceutical sciences and research. 3(11): 4235.
Merai A and Jadhav A (2014). Antiulcer activity of Carissa carandas using root extract in albino rats.World journal of pharmacy and pharmaceutical science. 3: 1314.
Mirje M and Uz zaman S (2014). Evaluation of antiulcer activity of ocimum sanctum(tulsi) in indomethacin nduced gastric ulcer in albino rats.Int. J. Lifesc. Bt & Pharma. Res. 3: 274.
Panda V and Sonkamble M (2012). Anti -ulcer activity of Ipomoeabatatas tubers (sweet potato). Functional foods in health and Disease. 2: 48.
Patil KS (2005). Wound healing activity of the seed kernels of Caesalpinia crista Linn. Journal of Natural Remedies. 5(1): 26.
Reddy VP, Sudheshna G, Afsar SK, Saran S, Kumar S, Raja ram C and Reddy KR (2012). Evaluation of anti-ulcer activity of citrulluscolocynthis fruit against pylorus ligation induced ulcers in male wistar rats. International Journal of Pharmacy and Pharmaceutical Sciences. 4: 446.
Sabrin F, Hasan MN, Islam KD, Rahman MM and Billah MM (2011). Investigation on antimicrobial activities of the two selected shrub from the sundarbans (Clerodendruminerme and Caesalpinia crista). J. Innov. Dev. Strategy. 5(2): 62-69.
Shah SJ and Patel JR (2012). Antiulcer activity of lucer against experimentally induced gastric ulcer in rats. Phisiol. Pharmacol. 33(2): 314-316.
Sharma G, Dubey SK, Sati N and Sanadya J (2011). Ulcer healing potential of Aeglemarmelos fruit seed. Asian journal of pharmacy and life science. 1(2): 172.
Tripathi KK, Bhowmik D and Sampathkumar KP (2010). Recent trends of treatment and medication peptic ulcerative disorder. International journal of pharmatech research. 2(1): 970-980.
