Formulation Development and In vitro Evaluation of Controlled Release Gliclazide Trilayer Matrix Tablets by Geomatrix Technology
DOI:
https://doi.org/10.37285/ijpsn.2019.12.1.7Abstract
Gliclazide an oral anti-diabetic drug used to treat type 2 diabetes mellitus. The purpose of the present study was to develop and optimize multi-layered matrix tablets of gliclazide trilayer tablets to achieve zero-order drug release for sustained plasma concentration. Gliclazide tablets were prepared by direct compression and consist of middle active layer with different grades of hydroxypropyl methylcellulose (HPMC K 4M, K 15M and K100M), Guar gum and Eudragit L 100. The tablets were also evaluated for physicochemical characteristics and release kinetics. The physicochemical characteristics of the prepared tablets were satisfactory. The developed drug delivery systems showed prolonged drug release rates over a period of 24 h. The release profile of the optimized formulation (EF14) was described by the Zero-order and Higuchi model. These studies show the viability of controlled release formulation of gliclazide using trilayer matrix approach.
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Keywords:
Gliclazide, Trilayer matrix tablet, HPMC, Guar gum, Release, Kinetics
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