Development and Evaluation of Fast Disintegrating Tablets of Lornoxicam Solid Dispersions
DOI:
https://doi.org/10.37285/ijpsn.2019.12.4.4Abstract
Lornoxicam is a nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class. It belongs to BCS class II substance with low solubility and high permeability. The aim of current research is to formulate solid dispersion incorporated Fast disintegrating tablets of Lornoxicam to enhance the dissolution rate and aqueous solubility and to enable faster onset of action. Solid dispersions are prepared with polymers like Kolliwax GMS, Soluplus and HPMC in three different ratios 1:1:1, 1:2:1 and 1:3:1. Formulations were characterized for drug content studies, drug release studies, and drug-polymer interactions using Fourier transform infrared spectroscopy (FTIR) spectrum. The solid dispersions can be evaluated by in-vitro dissolution studies. The optimized solid dispersion SD9 was further used to prepare fast disintegrating tablet by direct compression method using 33 Response surface method (3 variables and 3 levels of superdisintegrants) by using Design of experiment software with superdisintegrants like locust bean gum, gum karaya, Plantago ovata. The values of pre-compression parameters evaluated were within prescribed limits that indicated good free flowing properties. The data obtained of post-compression parameters such as weight variation, hardness, friability, content uniformity, disintegration time (33 sec) and percentage drug release was maximum in LF24 (99.21±1.87%) within 10 minutes and was found to superior over Marketed formulation i.e., 87.27±0.27 %. From in vivo bioavailability studies the best formulation has shown Tmax of 1.0 h which was highly significant (P < 0.05) when compared with marketed formulation 2.5 h. The statistical significance was assessed by one-way analysis of variance. Therefore, the solid dispersions incorporated fast disintegrating tablets of Lornoxicam can be successfully used for improvement of dissolution, resulted in faster onset of action as indicated by in vivo studies. It can be concluded that fast disintegrating tablets using Lornoxicam solid dispersion could be used to improve better patient compliance with immediate action in the effective management of pain and inflammation.
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Keywords:
Lornoxicam, NSAID’s, Solid dispersion, Fast-disintegrating, Pharmacokinetics
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References
Ali S and Quadir A (2017). High molecular weight povidone polymer-based films for fast dissolving drug delivery applications. Drug Del Technol 7(6): 36-43.
Arun Prasad K, Narayanan N and Raja Lakshmi G (2010). Preparation and evaluation of solid dispersion of terbinafine hydrochloride. Int J Pharm Sci Rev Res 3(1):130-134.
Breitenbach J(2002). Melt extrusion from process to drug delivery technology. Eur J Pharm Biopharm 54: 107–117.
Corniello C (2016). Quick dissolving strips from concept to commercialization. Drug Del Technol 6 (2): 68–71.
Dhirendra K, Lewis S, Udupa N and Atin K (2009). Solid Dispersions: A Review. Pak J Pharm Sci 22(2):234-246.
Dipika M, Ojha Kumar P, Nandy Chandra B and Kanta Lakshmi G (2010). Effect of Carriers on Solid Dispersions of Simvastatin (Sim): Physico- Chemical Characterizations and Dissolution Studies. Der Pharmacia Lettre 2(4): 47-56.
Ganesh C, Patel P, Hardikar S, Kelkar M, Ashok B and Sagar B (2009). Formulation and Evaluation of Solid Dispersions of Furosemide in Sodium Starch Glycolate. Trop J Pharm Res 8(1): 43-51.
Higuchi T and Connors K (1965). Phase-solubility techniques. Adv Anal Chem Instrum 4:117-212.
Izhar Kasid, Rozeena Parveen, Nikhat Parveen, Aijaz A and Sandip Sapkal (2013). Formulation and Evaluation of solid dispersion incorporated mouth dissolving tablet of Gliclazide. Int J Drug Dev & Res 5(1): 377-383.
Lakshmi K, Pranav Kumar M and Rajesh Kaza (2012). Dissolution enhancement of Telmisartan by surface solid dispersion technology. International Journal of Innovative Pharmaceutical Research 3(4): 247-251.
Leuner C and Dressman J (2000). Improving Drug Solubility for Oral Delivery Using Solid Dispersions. European J Pharm Sci 50: 54-55.
Metker V and Kumar A (2011). Formulation and evaluation of oro dispersible tablets of lornoxicam. Int J Drug Dev & Res 3 (1): 281-285.
Mishra R and Amin A (2013). Quick API Delivery. Pharm Tech Eur 19(10): 35-39.
Nagamani B, Chandra Sarat, Koteswara Rao GSN and Devi P(2013). Improvement of simvastatin solubility using natural polymers by solid dispersion technique. International Journal of Pharmaceutical Research and Biomedical Analysis 2(2): 01- 06.
Niranjan B, Swati Rawat and Upendra G (2013). Formulation and Evaluation of Oral Disintegrating Tablets of Lornoxicam by 32 Factorial Designs. J Appl Pharm Sci 3(1):42-52.
Pankaj Kumar A, Shubhanjali Shuklab, B.B. Subudhia and Ashok Laxmanrao Ganure (2012). A Bio analytical Method Development and Validation for the Simultaneous Estimation of Thiocolchicoside and Lornoxicam in Human Plasma and in Pharmaceutical Dosage Form by RP-HPLC. Int J Pharm. Sci 4(3): 252-259.
Patel Anuradha, Prajapati Parixit, Boghra Rikisha and Shah Dipti (2011). Solubility enhancement of poorly aqueous soluble Furosemide using peg-4000 by solid dispersion. Asian Journal of Pharmaceutical Sciences and Clinical Research 22(1): 1-9.
Patel RA and Prajapati SD (2013). Fast dissolving tablets as a newer venture in fast dissolving dosage forms. Int J Drug Dev & Res 2(2): 232-246.
Priyanka Shrestha, Shiva Kumar Bhandari, Ashraful Islam SM and Santosh A (2014). Dissolution Enhancement of Glimepiride by Solid Dispersion Technique. Res J Pharm Biol Chem Sci 5(5): 977.
Rajnikant M, Narendra P and Digesh D (2013). Formulation and Evaluation of Fast Dissolving Tablets of Ondansetron by Solid Dispersion in Super disintegrants. IJPER 47(3): 49-55.
Ritesh F, Tarique Ali, Purnima Amin and Shyam G (2013). Preparation and characterisation of lornoxicam solid dispersion systems using hot melt extrusion technique. J Pharm Investing 44(1): 1-16.
Shamma Rehab N and Basha Mona (2013). A novel polymeric solubilize for optimization of Carvedilol solid dispersions Formulation design and effect of method of preparation. Powder Technol 237: 406-414.
Shashidhar Reddy Dodda and Prakash Rao Boggrapu (2012). Development and in Vitro-in Vivo Evaluation of Controlled Release Matrix Tablets of Desvenlafaxine. Pharmacology & Pharmacy 3: 15-19.
Sonam Ranga, Manish J, Sanjay Kumar S, Bhupendra Singh C and Amit Kumar A (2014). Review on Design of Experiments (DOE). IJCPS 3(1): 216-224.
