Drug and Gene Delivery Carriers:Biodegradable and Biocompatible




  • Deeksha Kumari
  • Bikash Medhi



In the area of modern medicine and biotechnology drug and gene delivery optimize the pharmacokinetics and pharmacodynamics for the safety and effective transport of therapeutic agents to the targeted area in the body. 

Biodegradable and biocompatible carriers have been explored as biomaterials for nearly two decades in gene delivery and tissue engineering1. This biomaterial has been actively researched as a prospective carrier for delivering therapeutic medicines and genes due to their physiochemical properties, decreased toxicity, and immunogenicity. These materials might be natural/biological or synthetic in origin, and their unique features provide several benefits, a wide range of pharmaceutical approaches for building micro-and nano-vehicles of medicinal medicines and genes2.


Download data is not yet available.


Metrics Loading ...


Drug Delivery



How to Cite

Kumari D, Medhi B. Drug and Gene Delivery Carriers:Biodegradable and Biocompatible . Scopus Indexed [Internet]. 2023 Sep. 15 [cited 2024 Feb. 26];16(5):6943-4. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/3981


1. Zhao, Z., Wang, J., Mao, H. Q., & Leong, K. W. (2003). Polyphosphoesters in drug and gene delivery. Advanced drug delivery reviews, 55(4), 483–499. https://doi.org/10.1016/s0169-409x(03)00040-1.
2. Lee, S.Y.; Kim, S.Y.; Ku, S.H.; Park, E.J.; Jang, D.-J.; Kim, S.T.; Kim, S.-B. Polyhydroxyalkanoate Decelerates the Release of Paclitaxel from Poly(lactic-co-glycolic acid) Nanoparticles. Pharmaceutics. 2022. 14, 1618. https://doi.org/10.3390/pharmaceutics14081618
3. W. Chen, et al., Advanced drug and gene delivery systems based on functional biodegradable polycarbonates and copolymers. J. Control. Release. 2014. http://dx.doi.org/10.1016/j.jconrel.2014.05.023.
4. Maira Anwar, Faqir Muhammad, Bushra Akhtar. Biodegradable nanoparticles as drug delivery devices. Journal of Drug Delivery Science and Technology. Volume 64. 2021. 102638. ISSN 1773-2247. https://doi.org/10.1016/j.jddst.2021.102638.
5. Mahapatro A, Singh DK. Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines. J Nanobiotechnology. 2011 Nov 28;9:55. doi: 10.1186/1477-3155-9-55. PMID: 22123084; PMCID: PMC3238292.
6. Chen CK, Huang PK, Law WC, Chu CH, Chen NT, Lo LW. Biodegradable Polymers for Gene-Delivery Applications. Int J Nanomedicine. 2020;15:2131-2150. https://doi.org/10.2147/IJN.S222419.
7. Xingran Kou, Qixuan Zhao, Wenwen Xu, Zuobing Xiao, Yunwei Niu, and Kai Wang.Biodegradable Materials as Nanocarriers for Drugs and Nutrients.Journal of Renewable Materials. 2020. DOI: 10.32604/jrm.2021.015268.
8. Din, F. U., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., & Zeb, A. (2017). Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. International journal of nanomedicine, 12, 7291–7309. https://doi.org/10.2147/IJN.S146315
9. Namiot, E. D., Sokolov, A. V., Chubarev, V. N., Tarasov, V. V., & Schiöth, H. B. (2023). Nanoparticles in Clinical Trials: Analysis of Clinical Trials, FDA Approvals and Use for COVID-19 Vaccines. International journal of molecular sciences, 24(1), 787. https://doi.org/10.3390/ijms24010787.
10. M.L Hans, A.M Lowman. Biodegradable nanoparticles for drug delivery and targeting. Current Opinion in Solid State and Materials Science. Volume 6, Issue 4. 2002. Pages 319-327. ISSN 1359-0286. https://doi.org/10.1016/S1359-0286(02)00117-1.
11. Calzoni, E., Cesaretti, A., Polchi, A., Di Michele, A., Tancini, B., & Emiliani, C. (2019). Biocompatible Polymer Nanoparticles for Drug Delivery Applications in Cancer and Neurodegenerative Disorder Therapies. Journal of functional biomaterials, 10(1), 4. https://doi.org/10.3390/jfb10010004.
12. Sang-oh Han, Ram I. Mahato, Yong Kiel Sung, Sung Wan Kim. Development of Biomaterials for Gene Therapy. Molecular Therapy. Volume 2, Issue 4. 2000. Pages 302-317. ISSN 1525-0016. https://doi.org/10.1006/mthe.2000.0142.
13. Su, Shi & Kang, Peter.Systemic Review of Biodegradable Nanomaterials in Nanomedicine. Nanomaterials. 2020 10. 656. 10.3390/nano10040656.

Most read articles by the same author(s)

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.