Formulation Evaluation and Optimization of Stomach Specific In situ Gel of Ranitidine Hydrochloride
DOI:
https://doi.org/10.37285/ijpsn.2010.3.1.6Abstract
The objectives of this research work were preparation, optimization and evaluation of in situ gelling system of Ranitidine. HCl based on sodium alginate that retains in the stomach by adherence to gastric wall providing an increased gastric residence time resulting in prolonged drug delivery in gastrointestinal tract. Sodium alginate was used as a polymer and CaCO3 as a cross-linking agent. The in situ formulation exhibited the expectations, viscosity, drug content and sustained drug release. This study reports that oral administration of aqueous solutions containing sodium alginate results in formation of in situ gel and such formulations are homogenous liquids when administered orally and become gel at the contact site. The results of a 32 full factorial design revealed that the concentrations of sodium alginate and CaCO3 significantly affected the dependent variables of viscosity, Q50 and Q80. These in situ gels are, thus, suitable for oral sustained release of Ranitidine HCL.
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