Taste Masking of Topiramate by Newer Range of Ion-Exchange Resin
DOI:
https://doi.org/10.37285/ijpsn.2010.3.3.8Abstract
Topiramate, is an anti-epileptic drug used to treat partial onset seizures, or primary generalized tonic-clonic seizures in children and adults. But its bitter taste became a critical issue which strongly demanded to mask the taste. Different types of ion exchange resins like Kyron T-104, Kyron T-114, Kyron T-134, Doshion P 542 were used to form complex with Topiramate. Ion exchange resin to drug ratio, effect of pH, effect of temperature, effect of resin soaking time, effect of stirring time on complex formation were optimized. Drug-resin complex was evaluated for swelling, particle size analysis and drug release from drug-resin complex. Developed taste masked drug candidate in this research work become eligible to formulate mouth disintegrating dosage form.
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Keywords:
Topiramate, taste masking, ion-exchange resin, Drug-resin complex, Kyron, Doshion
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References
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