"Effect of Hydrophilic and Hydrophobic Polymers and in vitro Evaluation of Hydro – Dynamically Balanced System of Metoclopramide Hydrochloride"
DOI:
https://doi.org/10.37285/ijpsn.2010.3.3.11Abstract
Objective of present studies was to develop Hydro-dynamically Balanced system (HBS) of Metoclopramide Hydrochloride by non-effervescent technique. Different grades of polymers were used for prolonging release and flotation of the capsule. In order to study effect of concentration of release retardant, formulations of different combinations were studied. The floating capsules were evaluated for drug content, floating behavior, weight variation and in-vitro dissolution. After fitting the dissolution data into various models like zero order, first order, Higuchi, Hixson-Crowell and Korsmeyer’s-Peppas, the selected formulation was found to follow Higuchi model with Fickian diffusion mechanism. Stability studies were carried out at 40°C/75% RH for 6 months and results showed no significant changes in physical appearance, floating behavior, and drug content. These experimental clearly indicated that metoclopramide HCl floating drug delivery systems may be formulated to match patient compliances.
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Keywords:
Metoclopramide, Floating capsules, release retardant, significant changes, Higuchi model
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Arora S, Ali J, Ahuja A, Khar RK, Baboota S. Floating drug delivery systems: a review. AAPS PharmSciTech.; 6
E372YE390,2005.
British Pharmacopoeia, “Metoclopramide Hydrochloride” Vol II, 3921-3923, 2009.
Chen GL, Hao WH. In vitro performance of floating sustained release capsule of verapamil. Drug Dev Ind Pharm. 24:
Y1072, 1998.
Garg S., Sharma S.: Business Briefing Pharmatech 160, 66, 2003.
Higuchi T. Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci.; 50:874Y875,
Hixson AW, Crowell JH. Dependence of reaction velocity upon surface and agitation: theoretical considerations. Ind Eng
Chem.; 23:923Y93, 1931.
International Conference on Harmonization Steering Committee. Q1A - Stability Testing of New Drug Substance and Products, 1999.
Javed Ali et al. Formulation and Development of Floating Capsules of Celecoxib: In Vitro and In Vivo Evaluation. AAPS PharmSciTech; 8 (4) Article 119, 2007.
Kim C.J.: Dosage Form Design, Lancaster: Technomic Pub;Basel, 2000
Korsmeyer RW, Deolkar GEP, Peppas NA. Mechanisms of potassium chloride from compressed, hydrophilic, polymeric matrices: effect of entrapped air. J Pharm Sci. 1983; 72:1189Y1191.
Lachmann L. et al, “Theory and Practices of Industrial Pharmacy, Ideal Publications, 300.
N. K. Jain, “Controlled and Novel Drug Delivery”, CBS publishers and distributors, 3-4.
Satoskar R.S., et al, “Pharmacology and Pharmacotherapeutics”, Popular Prakashan, Revised 21st edition, 587-588, 2008.
Saxena M. et al; “Formulation and Evaluation of Transdermal Patches of Metoclopramide Hydrochloride” Indian drugs, Vol: 43.No.9, 740.
Singh B.N., Kim K.H.: J. Control. Release 63, 235, 2000.
Watanabe S, Kayano M, Ishino Y. US Patent No., 3,976,197
