Formulation and Evaluation of Sumatriptan Succinate Fast Disintegrating Films and Tablets

DOI:

https://doi.org/10.37285/ijpsn.2013.6.2.11

Authors

  • Y. Shravan Kumar
  • R Gowthami
  • Sujitha H
  • Nagaraju T
  • Rajashekar M
  • Murali Krishna Kumar
  • Y. Madhusudhan Rao

Abstract

Sumatriptan succinate is a 5-HT1B/1D receptor agonist which has well established efficacy in treating migraine. The main objective of the study was to formulate Oral Fast Disintegrating Films (ODF) and Oral Fast Disintegrating Tablets (ODT) to achieve a better dissolution rate and further improving the bioavailability of the drug.  ODFs were prepared by solvent casting method using film forming polymers like HPMC – E15,5cps,50cps in different ratios & prepared batches of films were evaluated for the drug content, film thickness, disintegration time  and in vitro dissolution studies. Among the prepared formulation F7 containing HPMC – 50cps (drug: polymer ratios = 1:1) was found to be best formulations which releases 98.2±1.1of the drug within 17±0.02 sec. ODTs prepared by direct compression method using in different concentrations of super-disintegrants. The prepared formulation T12 (combination of disintegrants) containing CP + CCS (6%) was considered to be the best formulation, which releases up to 100±0.38% of the drug in 23±0.75 sec, respectively. Based on these results, it is suggested that ODFs have faster disintegration time and drug release than ODTs.

 

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Keywords:

Oral Fast Disintegrating Films, Oral Fast Disintegrating Tablets, Sumatriptan Succinate, Crospovidone, Croscarmellose sodium, Sodium starch glycollate

Downloads

Published

2013-08-31

How to Cite

1.
Kumar YS, Gowthami R, H S, T N, M R, Kumar MK, et al. Formulation and Evaluation of Sumatriptan Succinate Fast Disintegrating Films and Tablets. Scopus Indexed [Internet]. 2013 Aug. 31 [cited 2024 Dec. 26];6(2):2087-96. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/625

Issue

Vol. 6 No. 2 (2013): July-September 2013

Section

Research Articles
Crossref
Scopus
Google Scholar
Europe PMC

References

Abdelbary A, Elshafeey AH and ZidanG (2009). Comparative effects of different cellulosic-based directly compressed orodispersable tablets on oral bioavailability of famotidine. J Carbohydrate Polymers 77: 799-806.

Arun A, Amrish C, Vijay S and Kamla P (2009) . Fast dissolving oral films: an innovative drug delivery system and dosage form. Int J ChemTech Res 2(1): 576-583.

Bhupendra GP and Ratnakar N (2009). A review on recent patents on fast dissolving drug delivery system. Int J Pharm Tech Res 1(3): 790-798.

Charyulu R (2010). An emerging trend in oral drug delivery technology: Rapid disintegrating Tablets. J Pharm Sci Tech. 2 (10): 318-329.

Debjit B, Chiranjib B, Krishnakanth P and Margret Chandira P (2009). Fast dissolving tablet: an Overview. J Chem Pharm Res 1(1): 163-177.

Gavaskar B., Subash Vijaya K, Guru Sharan and Madhusudan Rao Y (2010). Overview on fast dissolving films. Int J Pharmacy Pharm Sci 2(3): 29-33.

Hiroyoshi S, Kazumi T, Misao N, Katsuhiko M, Tadao T, Hirotaka Y, Naoki I, Kazuyuki H, Mayumi Y, Yasutomi K and Yoshinori I (2009). Preparation of a fast dissolving oral thin film containing dexamethasone: A possible application to antiemesis during cancer chemotherapy. Eur J Pharm. Biopharm 73: 361–365.

Hisakadzu S and Yunxia (2002). Preparation, evaluation and optimization of rapidly disintegrating tablets. J. Powder Tech 122: 188-198.

Jaysukh JH, Dhaval AR and Kantilal RV (2009). Orally Disintegrating Tablets: A Review, Tropical. J Pharm Res 8 (2): 161-172.

Jeevanandham S, Dhachnamoorthi D, Chandrasekhr KB, Muthukumaran M, Sriram N and Joysarb J(2010). Formulation and evaluation of naproxen sodium orodispersible tablets - a sublimation technique. Asian J Pharm 11: 49-51.

Kiran Bhaskar D, More MR, Sockan GN, Kunchu K and Mani T (2011). Formulation and evaluation of orodispersible tablets of propranolol hydrochloride. Int J Pharm Res Dev 2(12): 46-52.

Kuldeep M, Kevin G, Biswajit B, Ravi B, Bhavik J, Narayana Mohanachandran PS, Krishna Mohan PR, Fels Saju, Bini KB, Beenu B and Shalina KK (2010). Formulation and evaluation of mouth dispersible tablets of amlodipine Besylate. Int J Appl Pharma 2(3): 16.

Kulkarni AS, Deokule HA, Mane MS and Ghadge DM (2010). Exploration of different polymers for use in the formulation of oral fast dissolving strips. J Cur Pharm Res 2(1): 33-35.

Nehal S, Garima G and Pramod Kumar S (2010). Fast dissolving tablets: preparation, characterization and evaluation: an overview. Int J Pharm Sci Rev Res 4(2): 87-96.

Puttewar TY, Kshirsagar MD, Chandewar AV and Chikhale RV (2010). Formulation and evaluation of taste masked doxylamine succinate using ion exchange resin. J. King Saudi University 22: 229-240.

Rangasamy M (2009). Oral disintegrating tablets: a future compaction. Int J Pharma Res Dev Online 1(10): 1-10.

Sandeep D, Kavitha K and Ganesh NS (2011). Fast disintegrating tablets – An emerging trend. Int J Pharm Sci Rev Res 6(2): 18-22.

Siraj S, Khirsagara RV and Aamer Q (2010). Fast disintegrating tablets: an overview of formulation and technology. Int J Pharmacy Pharm Sci 2(3): 9-15.

Tejvir K, Bhawandeep G, Sandeep K and Gupta GD (2011). Mouth dissolving tablets: a novel approach to drug delivery. Int J Curr. Pharm Res 3(1): 17.