Targeting Aspects of Nanogels: An Overview
DOI:
https://doi.org/10.37285/ijpsn.2014.7.4.3Abstract
Nanogels have shown a great potential for the delivery of large number of drugs to different organs of the body owing to their high biocompatibility, high drug loading capacity, high biodegradability (and hence low cytotoxicity), good permeation capabilities and tissue mimicking properties. Their high water retention makes them ideal capable of incorporation of bulky drugs like proteins, peptides, oligonucleotides and other macromolecules. All these properties of nanogels make them able to carry number of drugs to vast number of organs. Nanogels have shown potential in many fields including chemotherapy, diagnosis, organ tergeting, gene delivery and many others. The main areas of the target for the nanogels have been tumors of brain, liver, skin etc. Other uses of the nanogel are in diabetes, inflammation, wound healing, local anesthesia etc. This review concentrates over the targeting potential of nanogels in different organs for various conditions.
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Keywords:
Nanogel, Polymer, Swelling, Loading capacity, Organ targeting, Cancer therapy
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