Recent Advances in Self-Emulsifying Drug Delivery Systems
DOI:
https://doi.org/10.37285/ijpsn.2015.8.1.1Abstract
Oral route has always been preferred route for formulators and has dominated over other routes of administrations. But major problem encountered in oral formulations (as estimated more than 50 % of oral formulations are found to be poorly aqueous soluble), is low bioavailability, giving rise to further problems like, high inter and intra subject variability, lack of dose uniformity and finally leading to therapeutic failure. Approximately 40% of new chemical entities exhibit poor aqueous solubility and present a major challenge to modern drug delivery system, because of their low bioavailability. Particularly for BCS class II substances, the bioavailability may be enhanced by increasing the solubility and dissolution rate of the drug in the gastro-intestinal fluids. The newer and novel technologies developed in recent year for troubleshooting such above problems. This review describes an overview of SEDDS as a capable approach to effectively capture the problem of poorly soluble molecules and give the novel approaches for evaluation of the SEDDS. Self-emulsifying drug delivery systems (SEDDS) are isotropic mixtures of drug, lipids and surfactants, usually with one or more hydrophilic co-solvents or co-emulsifiers.
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Keywords:
Self-emulsifying delivery system, solvent, surfactant, cosurfactant
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References
Amidon GL, Lennernas H, Shah VP and Crison JR (1995). A Theoretical Basis for A Biopharmaceutical Drug Classification: The Correlation of In Vitro Drug Product Dissolution and In Vivo Bioavailability. Pharmaceutical Research, 12: 413-420.
Arijit G and Parimal M (2013). Self-Emulsifying Drug Delivery System: An Approach for Enhancement of Bioavailability of Poorly Water Soluble Drugs. International Journal of Pharmacy and Integrated Life Sciences, 1(6): 1-16.
Asija R, Yadav P and Asija S (2014). Self Emulsifying Drug Delivery System: A Promising Approach for Bioavailability Enhancement. International Journal of Research and Development in Pharmacy and Life Sciences, 3(2): 872-876.
Bhupinder M, Roy GS, Bajwa BS and Kumar S (2013). Self Emulsified Drug Delivery System for the Enhancement of Oral Bioavailability of Poorly Water Soluble Drugs. International Journal of Advances in Pharmacy, Biology and Chemistry, 2(3): 427-436.
Bose S and Kulkarni PK (2002). Self Emulsifying Drug Delivery Systems: A Review. Ind J Phar Edu, 36(4): 184-190.
Buckley S, Frank K, Fricker G and Brandl M (2013). Biopharma-ceutical Classification of Poorly Soluble Drugs with Respect to “Enabling Formulations”. European Journal of Pharmaceutical Sciences, 50(1): 8-16.
Dangi M, Madan J and Banode S (2011). Emulsion Based Drug Delivery System. Indian Journal of Novel Drug Delivery, 3(1): 2-8.
Deshmukh AS, Mahale VG and Mahajan VR (2014). Formulation and Characterization of Inclusion Complexes: A Review. Pharmtechmedica, 3(3): 476-480.
Goldberg A, Gibaldi M and Kanig J (1966). Increasing Dissolution Rates and Gastrointestinal Absorption of Drugs via Solid Solutions and Eutectic Mixtures II. Experimental evaluation of eutectic mixture: Urea-acetaminophen system. Journal of Pharm. Sci., 55(5): 482-487.
Goyal U, Gupta A, Rana A and Agrawal G (2012). Self Micro emulsifying Drug Delivery System: A Method for Enhancement of Bioavailability. International Journal of Pharmaceutical Sciences and Research, 3(1): 66-79.
Gupta R and Singh R (2009). Enhancement of Oral Bioavailability of Lipophilic Drugs from Self-Microemulsifying Drug Delivery System (SMEDDS). International Journal of Drug Development and Research, 1: 10-18.
Ingle L, Wankhade V, Udasi T and Tapar K (2013). New Approaches for Development and Characterization of SMEDDS. Inter-national Journal of Pharmacy and Pharmaceutical Science Research, 3(1): 7-14.
Kyatanwar A, Jadhav K and Kadam V (2010). Self Micro-Emulsifying Drug Delivery System (SMEDDS): Review. J Pharm Res, 3: 75-83.
Mishra N and Srivastava S (2009). New Strategy for Solubilization of Poorly Soluble Drug- SEDDS. Scholars Research Library, 1(2): 60-67.
Muranishi N, Kinugava M, Nakajima Y, Muranishi S and Sezakki H (1980). Mechanism for the Inducement of the Intestinal Absorption of Poorly Absorbed Drugs By Mixed Micelles, I: Effect of various Lipid-Bile Salt Mixed Micelles on The Intestinal Absorption of Streptomycin in The Rat. Int J Pharm., 4: 271-279.
Patel ND, Patel KV, Panchal LA, Shukla AK and Shelat PK (2011). An Emerging Technique for Poorly Soluble Drugs: Self Emulsifying Drug Delivery System. International Journal of Pharmaceutical and Biological Archives, 2(2): 621-629.
Patel PA, Chaulang GM, Kotkar AA, Mutha SS, Hardikar SR and Bhosale AV (2008). Self Emulsifying Drug Delivery System: A Review. Research J. Pharm. and Tech, 1(4): 313-323.
Sharma D, Soni M, Kumar S and Gupta G (2009). Solubility Enhancement – Eminent Role in Poorly Soluble Drugs. Research J. Pharm. and Tech, 2(2): 220-224.
Sharma S, Khinchi M, Sharma N, Agrawal D and Gupta M (2013). Approaches to Development of Solid-Self Micron Emulsifying Drug Delivery System: Formulation Techniques and Dosage Forms-A Review. Asian Journal of Pharmaceutical Research and Development, 1(5): 146-156.
Sunitha R, Sireesha DS and Aparna MVL (2011). Novel Self-Emulsifying Drug Delivery System- An Approach to Enhance Bioavailability of Poorly Water Soluble Drugs, International Journal of Research In Pharmacy and Chemistry, 1(4): 828-838.
