Solubility Enhancement Techniques for Poorly Water-Soluble Drugs
DOI:
https://doi.org/10.37285/ijpsn.2017.10.3.1Abstract
Solubility is the phenomenon of dissolution of solid in liquid phase to give a homogenous system. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for optimum pharmacological response. Poorly water-soluble drugs often require high doses in order to reach therapeutic plasma concentrations after oral administration. Poor aqueous solubility is a major problem encountered with formulation development of new chemical entities. There are over 40% of new chemical entities that exhibit poor solubility and low bioavailability. As per BCS classification system, these drugs comes under BCS class II that show poor solubility and high permeability. The bioavailability of these drugs can be dramatically improved by increasing the solubility of these drugs. This review article highlights a number of techniques for enhanc
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Keywords:
Solubility, BCS class II drugs, solubility enhancement, bioavailability
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Published
2017-05-31
How to Cite
1.
Deshmukh AS, Tiwari KJ, Mahajan VR. Solubility Enhancement Techniques for Poorly Water-Soluble Drugs. Scopus Indexed [Internet]. 2017 May 31 [cited 2024 Dec. 22];10(3):3701-8. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/839
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Section
Review Articles
References
Anjana MN, Joseph J and Nair SC (2013). Solubility Enhancement Methods- A Promising Technology for Poorly Water Soluble Drugs. International Journal of Pharmaceutical Sciences Review and Research 20(2): 127-134.
Attari Z, Bhandari A, Jagadish PC and Lewis S (2016). Enhanced ex-vivo intestinal absorption of Olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi Pharmaceutical Journal 24: 57-63.
Aulton ME (2002). Pharmaceutics: The science of dosage form design. Churchill Livingstone Publication. 2nd ed.: 15-32.
Babu PRS, Subrahmanyam CVS, Thimmasetty J, Manavalan R, Valliappan K and Kedarnath SA (2008). Solubility Enhancement of Cox-Ii Inhibitors by Co-solvency Approach. Dhaka University Journal of Pharmaceutical Sciences 7(2): 119-126.
Chandel P, Raj K and Kapoor A (2013). Liquisolid Technique: An Approach for Enhancement of Solubility. Journal of Drug Delivery & Therapeutics 3(4): 131-137.
Chaudhary A, Nagaich U, Gulati N, Sharma VK and Khosa RL (2012). Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education & Research 2(1): 32-67.
Dandagi PM, Kaushik S and Telsang S (2011). Enhancement of Solubility and Dissolution Property of Griseofulvin by Nanocrystallization. International Journal of Drug Development & Research 3(2): 180-191.
Desale SL, Deshmukh AS and Mahajan VR (2015). Solubility enhancement of poorly water-soluble drug Fenofibrate by inclusion complex. World Journal of Pharmacological Research and Technology 4(3): 242-255.
Deshmukh AS (2015). Recent advances in self-emulsifying drug delivery system. International Journal of Pharmaceutical Sciences and Nanotechnology 8(1): 1-5.
Deshmukh AS (2014). Solid Lipid Nanoparticles. Research Journal of Pharmaceutical Dosage Forms and Technology 6(4): 282-285.
Deshmukh AS and Mahajan VR (2015). Advanced delivery of poorly water-soluble drug Atorvastatin by lipid based formulation as SMEDDS. Asian Journal of Pharmaceutical Research and Development 3(2): 21-38.
Deshmukh AS and Mahajan VR (2015). Advanced delivery of poorly water-soluble drugs by lipid based formulation as SMEDDS. Asian Journal of Research in Biological and Pharmaceutical Sciences. 3(1): 14-24.
Deshmukh AS, Mahale VG and Mahajan VR (2014). Liquisolid compact techniques: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology 6(3): 161-166.
Dhapte V and Mehta P (2015). Advances in Hydrotropic Solutions: An Updated Review. St. Petersburg Polytechnical University Journal: Physics and Mathematics 1: 424-435.
Dhillon B, Goyal NK, Malviya R and Sharma PK (2014). Poorly Water Soluble Drugs: Change in Solubility for Improved Dissolution Characteristics a Review. Global Journal of Pharmacology 8(1): 26-35.
Furqan M, Thakkar VT, Soni TG, Gohel MC and Gandhi TR (2009). Supercritical fluid technology: A promising approach to enhance the drug solubility. Journal of pharmaceutical sciences and research 1(4): 1-14.
Gennaro AR (2000). Remington; The science and practice of Pharmacy. Lippincott Williams and Wilkins, 20th ed. Vol. 1.: 208-214.
Ghule PN, Deshmukh AS and Mahajan VR (2014). Floating Drug Delivery System (FDDS): An Overview. Research Journal of Pharmaceutical Dosage Forms and Technology. 6(3): 174-182.
Guo Y, Wang Y and Xu L (2015). Enhanced bioavailability of Rebamipide nanocrystal tablets: Formulation and in vitro/ in vivo evaluation. Asian journal of pharmaceutical sciences 10: 223-229.
Hecqa J, Deleers M, Fanara D, Vranckx H and Amighi K (2005). Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of Nifedipine. International Journal of Pharmaceutics 299: 167-177.
Jiao D, Jinfeng L and Shirui M (2015). Development and Evaluation of Vinpocetine Inclusion Complex for Brain Targeting. Asian journal of pharmaceutical sciences 10: 114-120.
Kapadiya N, Singhvi I, Mehta K, Karwani G and Dhrubo J (2011). Hydrotropy: A Promising Tool for Solubility Enhancement: A Review. International Journal of Drug Development & Research 3(2): 26-33.
Kumar K and Bhandari A (2013). Solubility and dissolution enhancement: Technologies and research emerged. Journal of Biological and Scientific Opinion 1(2): 105-116.
Kumar TA, Nirmala and Harikumar SL (2013). Various Techniques Enhancing Bioavailabilty of Poorly Water Soluble Drugs. Journal of Drug Delivery & Therapeutics 3(2): 215-221.
Kumar VS, Raja C and Jayakumar C (2014). A Review on Solubility Enhancement Using Hydrotropic Phenomena. International Journal of Pharmacy and Pharmaceutical Sciences. 6(6): 1-7.
Lua Y, Lib Y and Wu W (2016). Injected nanocrystals for targeted drug delivery. Acta Pharmaceutica Sinica B. 6(2): 106-113.
Mahale VG, Deshmukh AS and Mahajan VR (2014). Formulation and Characterization of Inclusion Complexes: A Review. Pharmtechmedica 3(3): 476-480.
Mandawgade SD, Sharma S, Pathak S and Patravale VB (2008). Development of SMEDDS using natural lipophile: Application to- Artemether delivery. International Journal of Pharmaceutics 362: 179-83.
Manogar PG, Hari BV and Devi DR (2011). Emerging Liquisolid Compact Technology for Solubility Enhancement of BCS Class-II Drug. Journal of Pharmaceutical Sciences and Research 3(12): 1604-1611.
Mehta H, Akhilesh D, Prabhakara P and Kamath JV (2012). Enhancement of Solubility by Complexation with Clyclodextrin and Nanocrystallisation. International Research Journal of Pharmacy. 3(5): 100-105.
Nalinishastri CN and Tadikonda RR (2012). Use of the Liquisolid Compact Technique for Improvement of the Dissolution Rate of Valsartan. Acta Pharmaceutica Sinica B 2(5): 502-508.
Naofumi H, Kayo Y, Haruka T and Chiaki O (2016). Development of nanocrystal formulation of mebendazole with improved dissolution and pharmacokinetic behaviors. Asian Journal of Pharmaceutical Sciences 11: 122-123.
Nayak AK and Panigrahi PP (2012). Solubility Enhancement of Etoricoxib by Cosolvency Approach. International Scholarly Research Network ISRN Physical Chemistry. Article Id 820653: 1-5.
Ojha N and Prabhakar B (2013). Advances in Solubility Enhancement Techniques. International Journal of Pharmaceutical Sciences Review and Research 21(2): 351-358.
Pant P, Bansal K, Rama P, Therdana R, Padhee K, Sathapathy A and Singh KP (2011). Micronization: An Efficient Tool for Dissolution Enhancement of Dienogest. International Journal of Drug Development & Research 3(2): 329-333.
Patel JN, Rathod DM, Patel NA and Modasiya MK (2012). Techniques to Improve the Solubility of Poorly Soluble Drugs. International Journal of Pharmacy & Life Sciences 3(2): 1459-1469.
Patil MS, Godse SZ and Saudagar RB (2013). Solubility enhancement by various techniques: An overview. World journal of Pharmacy and Pharmaceutical Sciences 2(6): 4558-4572.
Pentewar RS, Utikar M, Gaikwad SS, Thonte SS, Bhange M and Sugave RV (2015). A Review on Extraction of Herbal Drugs and the Enhancement of Solubility by Hydrotropy Technique. World Journal of Pharmaceutical Research 4(9): 614-623.
Prasad BSG, Gupta VRM, Devanna N, Rama DM, Rao GVV and Harish N (2012). Mixed Co-Solvency Concept: A Promising Tool To Enhance Solubility of Poor Soluble Drug Aceclofenac. International Journal of Pharmaceutical, Chemical and Biological Sciences 2(3): 338-342.
Rahman MM, Khalipha ABR, Azad MAK, Hossain S and Haque S (2014). Methods of Solubility and Dissolution Enhancement for Poorly Water Soluble Drugs: A Review. World Journal of Pharmacy and Pharmaceutical Sciences 3(5): 107-130.
Saini P, Kumar A and Visht S (2013). Spherical Agglomeration: A Novel Technique of Particulate Modification & Developing Niche Drug Delivery System. International Science Press 6(2): 86-101.
Sapra K, Sapra A, Singh SK and Kakkar S (2012). Self-Emulsifying Drug Delivery System: A Tool in Solubility Enhancement of Poorly Soluble Drugs. Indo Global Journal of Pharmaceutical Sciences 2(3): 313-332.
Saravana KK, Sushma M and Prasanna RY (2013). Dissolution Enhancement of Poorly Soluble Drugs by Using Complexation Technique– A Review. Journal of Pharmaceutical Sciences and Research 5(5): 120-124.
Saritha A, Shastri N, Sadanandam and Anantha L (2012). Enhancement of Dissolution and Anti- inflammatory Activity of Meloxicam by Spherical Agglomeration Technique. Journal of pharmaceutical Sciences and Research 4(1): 1657-1661.
Savjani KT, Gajjar AK and Savjani JK (2012). Drug Solubility: Importance and Enhancement Techniques. International Scholarly Research Network ISRN Pharmaceutics. Article ID 195727: 1-10.
Sharma N and Bharkatia M (2011). Solubility enhancement techniques: A review. International Journal of Pharmaceutical Erudition 1(3): 40-53.
Shekh I, Gupta V, Jain A and Gupta N (2011). Preparation and Characterisation of β- Cyclodextrin Aspirin Inclusion Complex. International Journal of Pharmacy & Life Sciences 2(4): 704-710.
Shinde PR, Parve BS, Rawat S and Rathod SS (2014). Different Approaches towards the Solubility Enhancement of Drug: A Review. World Journal of Pharmacy and Pharmaceutical Sciences 3(4): 625-646.
Singh N, Allawadi D, Singh S and Arora S (2013). Techniques for Bioavailability Enhancement of BCS Class II Drugs: A Review. International Journal of Pharmaceutical and Chemical Sciences 2(2): 1092-1101.
Sriamornsak P, Limmatvapirat S, Piriyaprasarth S, Mansukmanee P and Huang Z (2015). A New Self-Emulsifying Formulation of Mefenamic Acid with Enhanced Drug Dissolution. Asian Journal of Pharmaceutical Sciences 10: 121-127.
Thorat YS, Gonjari ID and Hosmani AH (2011). Solubility Enhancement Techniques: A Review on Conventional and Novel Approaches. International Journal of Pharmaceutical Sciences and Research 2(10): 2501-2513.
Vandana KR, Raju YP, Chowdary VH, Sushma M and Kumar NV (2014). An overview on in situ micronization technique– An emerging novel concept in advanced drug delivery. Saudi Pharmaceutical Journal 22: 283-289.
Vemula VR, Lagishetty V and Lingala S (2010). Solubility Enhancement Techniques. International Journal of Pharmaceutical Sciences Review and Research. 5(1): 41-51.
Wadher SJ, Gattani SG, Jadhav YA and Kalyankar TM (2014). Recent Approaches in Solubility Enhancement of Poorly Water Soluble Drug Simvastatin: A Review. World Journal of Pharmacy and Pharmaceutical Sciences 3(4): 366-384.
Yohei K, Koichi W, Manabu N, Shizuo Y and Satomi O (2011). Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications. International Journal of Pharmaceutics 420: 1-10
Zaheer A, Maurya N, Mishra KS and Khan I (2011). Solubility Enhancement of Poorly Water Soluble Drugs: A Review. International Journal of Pharmacy & Technology 3(1): 807-823.
Attari Z, Bhandari A, Jagadish PC and Lewis S (2016). Enhanced ex-vivo intestinal absorption of Olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi Pharmaceutical Journal 24: 57-63.
Aulton ME (2002). Pharmaceutics: The science of dosage form design. Churchill Livingstone Publication. 2nd ed.: 15-32.
Babu PRS, Subrahmanyam CVS, Thimmasetty J, Manavalan R, Valliappan K and Kedarnath SA (2008). Solubility Enhancement of Cox-Ii Inhibitors by Co-solvency Approach. Dhaka University Journal of Pharmaceutical Sciences 7(2): 119-126.
Chandel P, Raj K and Kapoor A (2013). Liquisolid Technique: An Approach for Enhancement of Solubility. Journal of Drug Delivery & Therapeutics 3(4): 131-137.
Chaudhary A, Nagaich U, Gulati N, Sharma VK and Khosa RL (2012). Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education & Research 2(1): 32-67.
Dandagi PM, Kaushik S and Telsang S (2011). Enhancement of Solubility and Dissolution Property of Griseofulvin by Nanocrystallization. International Journal of Drug Development & Research 3(2): 180-191.
Desale SL, Deshmukh AS and Mahajan VR (2015). Solubility enhancement of poorly water-soluble drug Fenofibrate by inclusion complex. World Journal of Pharmacological Research and Technology 4(3): 242-255.
Deshmukh AS (2015). Recent advances in self-emulsifying drug delivery system. International Journal of Pharmaceutical Sciences and Nanotechnology 8(1): 1-5.
Deshmukh AS (2014). Solid Lipid Nanoparticles. Research Journal of Pharmaceutical Dosage Forms and Technology 6(4): 282-285.
Deshmukh AS and Mahajan VR (2015). Advanced delivery of poorly water-soluble drug Atorvastatin by lipid based formulation as SMEDDS. Asian Journal of Pharmaceutical Research and Development 3(2): 21-38.
Deshmukh AS and Mahajan VR (2015). Advanced delivery of poorly water-soluble drugs by lipid based formulation as SMEDDS. Asian Journal of Research in Biological and Pharmaceutical Sciences. 3(1): 14-24.
Deshmukh AS, Mahale VG and Mahajan VR (2014). Liquisolid compact techniques: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology 6(3): 161-166.
Dhapte V and Mehta P (2015). Advances in Hydrotropic Solutions: An Updated Review. St. Petersburg Polytechnical University Journal: Physics and Mathematics 1: 424-435.
Dhillon B, Goyal NK, Malviya R and Sharma PK (2014). Poorly Water Soluble Drugs: Change in Solubility for Improved Dissolution Characteristics a Review. Global Journal of Pharmacology 8(1): 26-35.
Furqan M, Thakkar VT, Soni TG, Gohel MC and Gandhi TR (2009). Supercritical fluid technology: A promising approach to enhance the drug solubility. Journal of pharmaceutical sciences and research 1(4): 1-14.
Gennaro AR (2000). Remington; The science and practice of Pharmacy. Lippincott Williams and Wilkins, 20th ed. Vol. 1.: 208-214.
Ghule PN, Deshmukh AS and Mahajan VR (2014). Floating Drug Delivery System (FDDS): An Overview. Research Journal of Pharmaceutical Dosage Forms and Technology. 6(3): 174-182.
Guo Y, Wang Y and Xu L (2015). Enhanced bioavailability of Rebamipide nanocrystal tablets: Formulation and in vitro/ in vivo evaluation. Asian journal of pharmaceutical sciences 10: 223-229.
Hecqa J, Deleers M, Fanara D, Vranckx H and Amighi K (2005). Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of Nifedipine. International Journal of Pharmaceutics 299: 167-177.
Jiao D, Jinfeng L and Shirui M (2015). Development and Evaluation of Vinpocetine Inclusion Complex for Brain Targeting. Asian journal of pharmaceutical sciences 10: 114-120.
Kapadiya N, Singhvi I, Mehta K, Karwani G and Dhrubo J (2011). Hydrotropy: A Promising Tool for Solubility Enhancement: A Review. International Journal of Drug Development & Research 3(2): 26-33.
Kumar K and Bhandari A (2013). Solubility and dissolution enhancement: Technologies and research emerged. Journal of Biological and Scientific Opinion 1(2): 105-116.
Kumar TA, Nirmala and Harikumar SL (2013). Various Techniques Enhancing Bioavailabilty of Poorly Water Soluble Drugs. Journal of Drug Delivery & Therapeutics 3(2): 215-221.
Kumar VS, Raja C and Jayakumar C (2014). A Review on Solubility Enhancement Using Hydrotropic Phenomena. International Journal of Pharmacy and Pharmaceutical Sciences. 6(6): 1-7.
Lua Y, Lib Y and Wu W (2016). Injected nanocrystals for targeted drug delivery. Acta Pharmaceutica Sinica B. 6(2): 106-113.
Mahale VG, Deshmukh AS and Mahajan VR (2014). Formulation and Characterization of Inclusion Complexes: A Review. Pharmtechmedica 3(3): 476-480.
Mandawgade SD, Sharma S, Pathak S and Patravale VB (2008). Development of SMEDDS using natural lipophile: Application to- Artemether delivery. International Journal of Pharmaceutics 362: 179-83.
Manogar PG, Hari BV and Devi DR (2011). Emerging Liquisolid Compact Technology for Solubility Enhancement of BCS Class-II Drug. Journal of Pharmaceutical Sciences and Research 3(12): 1604-1611.
Mehta H, Akhilesh D, Prabhakara P and Kamath JV (2012). Enhancement of Solubility by Complexation with Clyclodextrin and Nanocrystallisation. International Research Journal of Pharmacy. 3(5): 100-105.
Nalinishastri CN and Tadikonda RR (2012). Use of the Liquisolid Compact Technique for Improvement of the Dissolution Rate of Valsartan. Acta Pharmaceutica Sinica B 2(5): 502-508.
Naofumi H, Kayo Y, Haruka T and Chiaki O (2016). Development of nanocrystal formulation of mebendazole with improved dissolution and pharmacokinetic behaviors. Asian Journal of Pharmaceutical Sciences 11: 122-123.
Nayak AK and Panigrahi PP (2012). Solubility Enhancement of Etoricoxib by Cosolvency Approach. International Scholarly Research Network ISRN Physical Chemistry. Article Id 820653: 1-5.
Ojha N and Prabhakar B (2013). Advances in Solubility Enhancement Techniques. International Journal of Pharmaceutical Sciences Review and Research 21(2): 351-358.
Pant P, Bansal K, Rama P, Therdana R, Padhee K, Sathapathy A and Singh KP (2011). Micronization: An Efficient Tool for Dissolution Enhancement of Dienogest. International Journal of Drug Development & Research 3(2): 329-333.
Patel JN, Rathod DM, Patel NA and Modasiya MK (2012). Techniques to Improve the Solubility of Poorly Soluble Drugs. International Journal of Pharmacy & Life Sciences 3(2): 1459-1469.
Patil MS, Godse SZ and Saudagar RB (2013). Solubility enhancement by various techniques: An overview. World journal of Pharmacy and Pharmaceutical Sciences 2(6): 4558-4572.
Pentewar RS, Utikar M, Gaikwad SS, Thonte SS, Bhange M and Sugave RV (2015). A Review on Extraction of Herbal Drugs and the Enhancement of Solubility by Hydrotropy Technique. World Journal of Pharmaceutical Research 4(9): 614-623.
Prasad BSG, Gupta VRM, Devanna N, Rama DM, Rao GVV and Harish N (2012). Mixed Co-Solvency Concept: A Promising Tool To Enhance Solubility of Poor Soluble Drug Aceclofenac. International Journal of Pharmaceutical, Chemical and Biological Sciences 2(3): 338-342.
Rahman MM, Khalipha ABR, Azad MAK, Hossain S and Haque S (2014). Methods of Solubility and Dissolution Enhancement for Poorly Water Soluble Drugs: A Review. World Journal of Pharmacy and Pharmaceutical Sciences 3(5): 107-130.
Saini P, Kumar A and Visht S (2013). Spherical Agglomeration: A Novel Technique of Particulate Modification & Developing Niche Drug Delivery System. International Science Press 6(2): 86-101.
Sapra K, Sapra A, Singh SK and Kakkar S (2012). Self-Emulsifying Drug Delivery System: A Tool in Solubility Enhancement of Poorly Soluble Drugs. Indo Global Journal of Pharmaceutical Sciences 2(3): 313-332.
Saravana KK, Sushma M and Prasanna RY (2013). Dissolution Enhancement of Poorly Soluble Drugs by Using Complexation Technique– A Review. Journal of Pharmaceutical Sciences and Research 5(5): 120-124.
Saritha A, Shastri N, Sadanandam and Anantha L (2012). Enhancement of Dissolution and Anti- inflammatory Activity of Meloxicam by Spherical Agglomeration Technique. Journal of pharmaceutical Sciences and Research 4(1): 1657-1661.
Savjani KT, Gajjar AK and Savjani JK (2012). Drug Solubility: Importance and Enhancement Techniques. International Scholarly Research Network ISRN Pharmaceutics. Article ID 195727: 1-10.
Sharma N and Bharkatia M (2011). Solubility enhancement techniques: A review. International Journal of Pharmaceutical Erudition 1(3): 40-53.
Shekh I, Gupta V, Jain A and Gupta N (2011). Preparation and Characterisation of β- Cyclodextrin Aspirin Inclusion Complex. International Journal of Pharmacy & Life Sciences 2(4): 704-710.
Shinde PR, Parve BS, Rawat S and Rathod SS (2014). Different Approaches towards the Solubility Enhancement of Drug: A Review. World Journal of Pharmacy and Pharmaceutical Sciences 3(4): 625-646.
Singh N, Allawadi D, Singh S and Arora S (2013). Techniques for Bioavailability Enhancement of BCS Class II Drugs: A Review. International Journal of Pharmaceutical and Chemical Sciences 2(2): 1092-1101.
Sriamornsak P, Limmatvapirat S, Piriyaprasarth S, Mansukmanee P and Huang Z (2015). A New Self-Emulsifying Formulation of Mefenamic Acid with Enhanced Drug Dissolution. Asian Journal of Pharmaceutical Sciences 10: 121-127.
Thorat YS, Gonjari ID and Hosmani AH (2011). Solubility Enhancement Techniques: A Review on Conventional and Novel Approaches. International Journal of Pharmaceutical Sciences and Research 2(10): 2501-2513.
Vandana KR, Raju YP, Chowdary VH, Sushma M and Kumar NV (2014). An overview on in situ micronization technique– An emerging novel concept in advanced drug delivery. Saudi Pharmaceutical Journal 22: 283-289.
Vemula VR, Lagishetty V and Lingala S (2010). Solubility Enhancement Techniques. International Journal of Pharmaceutical Sciences Review and Research. 5(1): 41-51.
Wadher SJ, Gattani SG, Jadhav YA and Kalyankar TM (2014). Recent Approaches in Solubility Enhancement of Poorly Water Soluble Drug Simvastatin: A Review. World Journal of Pharmacy and Pharmaceutical Sciences 3(4): 366-384.
Yohei K, Koichi W, Manabu N, Shizuo Y and Satomi O (2011). Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications. International Journal of Pharmaceutics 420: 1-10
Zaheer A, Maurya N, Mishra KS and Khan I (2011). Solubility Enhancement of Poorly Water Soluble Drugs: A Review. International Journal of Pharmacy & Technology 3(1): 807-823.
