A Review of Dendrimer-based Approach to Novel Drug Delivery Systems
DOI:
https://doi.org/10.37285/ijpsn.2015.8.3.3Abstract
Dendrimers are synthetic macromolecules having highly branched, three-dimensional nanoscale architecture with very low polydispersity and higher functionality. They are polymers bearing regular dendritic architectures and represent a novel class of systems which features modifiable surface groups, multi-functionality and nanoscale monodispersed size. These molecules can form covalent or noncovalent complexes with pharmaceutical compounds and act as vehicles for targeted drug delivery and controlled-release purposes. Complex formation with other compounds can be promoted, for example, by solvophobic/solvophilic interactions, hydrogen bonding, or ionic pairing or through chemical binding (conjugation) to their surface groups. This review discusses the advantages, properties, different type of dendrimers, their characterization, dendrimers-based products and their pharmaceutical application in drug delivery systems. Recent advances of dendritic polymers (targeting dendrimers to HIV infected macrophages in vitro and plasmid and doxorubicin co-delivery targeting to tumor) and future prospects of dendrimers are also briefly discussed. Overall, dendrimers are most important macro-molecules in the novel drug delivery system and they have various pharmaceutical as well as non-pharmaceutical applications.
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Dendrimers, Hypercores, Chiral dendrimers, Drug delivery, Micelles
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Achar S and Puddephatt RJ (1994). Organoplatinum Dendrimers formed by Oxidative Addition. Angewandte Chemie International Edition in English, 33: 847-849.
Alakhov VY, Moskaleva EY, Batrakova EV, Kabanov AV (1996). Hypersensitization of Multidrug-resistant Human Ovarian-Carcinoma cells by Pluronic p85 Block-copolymer. Bioconjugate Chemistry, 7: 209-216.
Albrecht M, Gossage RA, Lutz M, Spek AL and Van Koten G (2000). Diagnostic Organometallic and Metallodendritic Materials for SO2 Gas Detection: Reversible Binding of Sulfurdioxide to Arylplatinum (II) Complexes. Chemistry: A European Journal, 6:1431-1445.
Amidon GL, Lennernas H, Shah VP and Crison JR (1995). A Theoretical basis for a Biopharmaceutic Drug Classification: the Correlation of in vitro Drug Product Dissolution and in vivo Bioavailability, Pharmaceutical Research, 12: 413-420.
Asthana, A., Chauhan, A. S., Diwan, P. V., and Jain, N. K. (2005). Poly (amidoamine) (PAMAM) Dendritic Nanostructures for Controlled Site-specific Delivery of Acidic Anti-inflammatory Active ingredient. AAPS Pharm Sci Tech, 6: E535-E542.
Asthana, A.; Chauhan, A. S.; Diwan, P. V.; Jain, N. K. (2005). Poly(amidoamine) (PAMAM) Dendritic Nanostructures for Controlled Site-specific Delivery of Acidic Anti-inflammatory Active ingredient. AAPS Pharm. Sci. Technol, 27: 536-542.
Baars, M. W. P. L.; Kleppinger, R.; Koch, M. H. J.; Yeu, S. L. and Miejer, E. W. (2000). Angewandte Chemie International Edition in English, 39: 1285-1288.
Barbara K and Maria B (2001). Dendrimers: Properties and Applications. Acta Biochimica Polonica, 48: 199-208.
Barry, B. W. and El Eini, D. I. D. (1976). Solubilization of Hydrocortisone, Dexamethasone, Testosterone and Progesterone by Long-chain Polyoxyethylene Surfactants. Journal of Pharmacy and Pharmacology, 28: 210-218.
Barth, R.F, Adams, D.M, Soloway, A.H, Alam F and Darby, M.V, (1994). Boronated Starburst Dendrimer-Monoclonal Antibody Immunoconjugates: Evaluation as a Potential Delivery System for Neutron Capture Therapy. Bioconjugates Chemistry, 5: 58-66.
Beezer, A. E., King, A. S. H., Martin, I. K., Mitchel, J. C., Twyman, L. J and Wain, C. F. (2003). Dendrimer as Potential Drug Carrier: Encapsulation of Acidic Hydrophobes within Water Soluble PAMAM Derivatives. Tetrahedron, 59: 3873-3880.
Betley, T.A, Hessler, J.A, Mecke, A, Banaszak Holl, M.M, Orr, B.G, Uppuluri, S, Tomalia, D.A and Baker Jr, J.R, (2002). Tapping mode Atomic Force Microscopy Investigation of Poly (amidoamine) Core-shell Tecto (dendrimers) using Carbon Nanoprobes. Langmuir, 18: 3127-3133.
Bhadra, D., Bhadra, S. and Jain N.K. (2005). PEGylated Lysine based Copolymeric Dendritic Micelles for Solubilization and Delivery of Artemether. Journal of Pharmacy and Pharmaceutical Science, 8: 467-482.
Bhadra, D., Bhadra, S., Jain, S. and Jain, N.K. (2003). A PEGylated Dendritic Nanoparticulate Carrier of Fluorouracil. International Journal of Pharmaceutics, 257: 111-124.
Bielinska, A., Kukowska-Latallo, J.F Johnson, J Tomalia, D.A and Baker, J.R. (1996). Regulation of in vitro Gene Expression using Antisense Oligonucleotides or Antisense Expression Plasmids Transfected using Starburst PAMAM Dendrimers. Nucleic Acids Res, 24: 2176-2182.
Boiko, N., Zhu, X., Bobrovsky, A and Shibaev V (2001). First Photosensitive Liquid Crystalline Dendrimer: Synthesis, Phase Behavior and Photochemical Properties, Chemistry of Materials, 13: 1447-1452.
Brewster, M.E., Esters, K.S. and Bodor, N. (1990). An Intravenous Toxicity Study of 2Hydroxypropyl Beta Cyclodextrin, A Useful Drug Solubilizer, in Rats and Monkeys. International Journal of Pharmaceutics, 59: 231-240.
Brewster, M.E., Esters, K.S., Loftsson, T., Perchalski, R., Derendorf, H., Mullersman, G. and Bodor, N (1988). Journal of Pharmaceutical Science, 77: 981-985.
Broeren, M.A.C, van, J.L.J, Dongen, M, Pittelkow, J.B, Christensen, M.H.P and Genderen V, (2004). Multivalency in the Gas Phase: The Study of Dendritic Aggregates by Mass Spectrometry. Angewandte Chemie International Edition in English, 43: 3557-3562.
C. Dufes, C.I.F, Uchegbu, A.G and Schatzlein, (2005). Dendrimers in Gene Delivery. Advanced Drug Delivery Reviews, 57: 2177-2202.
Caminade, A.M and R, Laurent. (2005). Characterization of Dendrimers. Advanced Drug Delivery Reviews, 57: 2130-2146.
Chan, K.L.A and Kazarian, S.G, (2006). Journal of Combinatorial Chemistry, 8: 26-31.
Chapman, T, Hillyer, G. L, Mahan, E. J and Shaffer KA (1994). Journal of the American Chemical Society, 116: 11195-11196.
Chauhan, A.S, Sridevi, S, Chalasani, K.B, Jain, A.K, Jain, S.K, Jain, N.K and Diwan, P.V, (2003). Dendrimer-Mediated Transdermal Delivery: Enhanced Bioavailability of Indomethacin. Journal of Controlled Release, 90: 335-343.
Chen, H.T., Neerman, M.F. and E, E. Simanek (2004). Cytotoxicity, Hemolysis and Acute in vivo Toxicity of Dendrimers Based on Melanine, Candidate Vehicles for Drug Delivery. American Chemical Society, 126: 10044-10048.
Chen, W., Tomalia, D. A. and Thomas, J. L. (2000). Unusual Ph-Dependent Polarity for Ph-Responsive Conformational Changes. Macromolecules, 33: 9169-9172.
Cheng YY and Xu TW. (2005). European Journal of Medicinal Chemistry, 40: 1384-1389.
Cheng, N. Man., T. Xu., R. Fu., X. Wang., X. Wang and L. Wen (2007). Transdermal Delivery of Nonsteroidal Anti-Inflammatory Drugs Mediated by Polyamidoamine (PAMAM) Dendrimers. Journal of Pharmaceutical Science, 96: 595-602.
Cheng, Y. and Xu, T. (2005). Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-Steroidal Anti-Inflammatory Drugs in the Presence of Polyamidoamine Dendrimers, European Journal of Medicinal Chemistry, 40: 1188-1192.
Choi, Y., Thomas, T., Kotlyar, A and Baker, J.R. (2005). Synthesis and Functional Evaluation of DNA-Assembled Polyamidoamine Dendrimer Clusters for Cancer Cell-Specific Targeting, Chemical Biology, 12: 35-43.
Chu, B and Hsiao B, S. (2001), Small-Angle X-Ray Scattering of Polymers. Chemical Reviews, 10: 1727-1762.
Colinger M, (2002). Biological Applications of Dendrimers, Current Opinion in Chemical Biology 6: 742-748.
D’Emanuele, A., Jevprasesphant, J. P., Penny, J. and Attwood, D. (2004). The Use of A Dendrimer-Propranolol Prodrug to Bypass Efflux Transporters and Enhance Oral Bioavailability. Journal of Control. Release, 95: 447-453.
Devarakonda, B., Hill, R. A., de Villiers and M. M (2004). The Effect of Pamam Dendrimer Generation Size and Surface Functional Group on Aqueous Solubility of Nifedipine. International Journal of Pharmaceutics, 284: 133-140.
Devarakonda, B., Hill, R. A., Liebenberg, W., Brits, M., deVilliers, M. M. (2005), Comparison of the Aqueous Solubilization of Practically Insoluble Niclosamide by Polyamidoamine (Pamam) Dendrimers and Cyclodextrins, International Journal of Pharmaceutics, 300: 193-209.
Duncan, R. and Izzo, L., (2005). Dendrimer Biocompatibility and Toxicity, Advanced Drug Delivery Reviews, 57; 2215–2237.
Dutta T, Garg M and Jain NK. (2008), Targeting of Efavirenz Loaded Tuftsin Conjugated Poly(Propyleneimine) Dendrimers to HIV Infected Macrophages in vitro. European Journal of Pharmaceutical Sciences, 34: 181-189.
El-Sayed. M., Ginski, M., Rhodes, C and Ghandehari, H., (2002). Trans Epithelial Transport of Poly (Amidoamine) Dendrimers Across Caco-2 Cell Monolayers, Journal of Controlled. Release, 81: 355-365.
Emanuele, D., Jevprasesphant, A. R., Penny, R. J. and Attwood, D., (2004). In vitro Release of 5-Fluorouracil with Cyclic Core Dendritic Polymer. Journal of Controlled. Release, 95: 447-453.
Fischer, Li .Y., Ahlemeyer, B., Krieglstein, J. and Kissel, T., (2003). In vitro Cytotoxicity Testing of Polycations: Influence of Polymer Structure on Cell Viability and Shemolysis. Biomaterials., 24: 1121-1131.
Fischer, R., Ko¨hler, K., Fotin-Mleczek, M., and Brock, R. (2004), A Stepwise Dissection of the Intracellular Fate of Cationic Cell-Penetrating Peptides. Journal of Biological Chemistry, 279: 12625-12635.
Freeman, A.W and Frechet, J.M.J., (2001). Developments in the Accelerated Convergent Synthesis of Dendrimers, Dendrimers and Other Dendritic Polymers Edited by Jean M. Fre chet and Donald A. Tomalia., 91-101.
G. Shemer, O. Krichevski, T. Molotsky, I. Lubitz and A. B. Kotlyar, (2006), Chirality of Silver Nanoparticles Synthesized on DNA. Journal of the American Chemical Society, 128: 11006-11007.
Garzo´n, L. C. and Martı´nez, F. (2004). Temperature Dependence of Solubility for Ibuprofen in Some Organic and Aqueous Solvents, Journal of solution chemistry, 33: 1379-1395.
Gensch, T; Hofkens, J; Heirmann, A; Tsuda, K; Verheijen, W; Vosch T, et al, (1999). Fluorescence Detection from Single Dendrimers with Multiple Chromophores. Angewandte Chemie International Edition in English, 38: 3752-3756.
Grainger DW and Okano T. (2003). Biomedical Micro- and Nano-Technology. Advanced Drug Delivery Reviews, 55: 311-313.
Green, A. R. and Guillory, J. K. (1989). Heptakis(2,6-Di-O-Methyl)-β-Cyclodextrin Complexation with the Antitumor Agent Chlorambucil. Journal of Pharmaceutical Sciences, 78: 427-431.
Gref, R.. Minamitake, Y., Peracchia, M. T., Trubetskoy, V., Torchilin, V. and Langer, R. (1994). Biodegradable Long-Circulating Polymeric Nanospheres. Science, 263: 1600-1603.
Han L, Huang R, Li J, Liu S, Huang S and Jiang C. (2011). Plasmid pORF-hTRAIL and Doxorubicin Co-Delivery Targeting to Tumor using Peptide-Conjugated PAMAM Dendrimer, Biomaterials, 32: 1242-52.
Hawker C and Fréchet J.M.J. (1990). A New Convergent Approach to Monodisperse Dendritic Molecule. Journal of the Chemical Society, Chemical Communications, 15: 1010-1012.
Hawker C, Wooley KL and Fréchet JMJ (1993), Journal of the Chemical Society, Perkin Transactions, 1: 1287-1289.
Hawker CJ, Wooley KL and Frechet JMJ (1993). Journal of the Chemical Society, Perkin Transactions, 1(21): 300.
Hofkens, J, Verheijen, W, Shukla R, Dehaen W and De Schryver FC, (1998). Detection of A Single Dendrimer Macromolecule with A Fluorescent Dihydropyrrolopyrroledione (DPP) Core Embedded in A Thin Polystyrene Polymer Film, Macromolecules, 31: 14493-4497.
Hummelen, J.C., Van Dongen JLJ and Meijer EW, (1997). Electrospray Mass Spectrometry of Poly (Propylene Imine) Dendrimers: The Issue of Dendritic Purity or Polydispersity, Chemistry: A European Journal, 31: 1489– 1493.
Hussan, M. A., Suleiman, M. S. and Najib N. M. (1990), International Journal of Pharmaceutics, 58(1): 19-24.
J. Cohen, (1995), Biochemistry - Getting All Turned Around Over the Origins of Life on Earth, Science, 267: 1265–1266.
Jain, N.K and. Khopade, A.J., (2001), Dendrimers as Potential Delivery Systems for Bioactives. In: N.K. Jain, Editor, Advances In Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, 361-380.
Kaanumalle, L. S., Nithyanandhan, J., Pattabiraman, M., Jayaraman, N. and Ramamurthy, V. (2004). J. Am. Chem. Soc. 126: 8999-9006.
Kallos, GJ., Tomalia DA., Hedstrand, DM., Lewis S and Zhou J. (1991). Molecular Weight Determination of A Polyamidoamine Starburst Polymer by Electrospray-Ionization Mass Spectrometry, Rapid Commun. Mass Spectrom, 5: 383-386.
Kannan S, Kolhe P, Raykova V, Glibatec M, Kannan RM, Lieh-Lai M and Bassett D (2004). Dynamics of Cellular Entry and Drug Delivery by Dendritic Polymers into Human Lung Epithelial Carcinoma Cells. Journal of Biomaterials Science, Polymer, 15: 311-330.
Kataoka, K., Kwon, G. S., Yokoyama, M., Okano, T. and Sakurai, Y. (1993). Block-copolymer Micelles as Vehicles for Drug Delivery. Journal of Controlled Release, 24: 119-132.
Khopade, A. J., Caruso, F., Tripathi, P., Nagaich, S. and Jain, N. K. (2002). Effect of Dendrimer on Entrapment and Release of Bioactive from Liposomes. International Journal of Pharmaceutics, 232: 157-162.
Kim YH and Webster OW (1990). Water Soluble Hyper Branched Polyphenylene: a Unimolecular Micelle. Journal of the American Chemical Society, 112: 4592-4593.
Kim, S. Y., Shin, I. L. G., Lee, Y. M., Cho, C. S. and Sung, Y. K. (1998), Methoxy Poly (ethylene glycol) and ε-caprolactone Amphiphilic Block Copolymeric Micelle Containing Indomethacin.: II. Micelle Formation and Drug Release Behaviours, Journal of Controlled Release, 51: 13-21.
Kobayashi, H.S., Kawamoto, T., Saga, N., Sato, A., Hiraga, T., Ishimori, J., K, Togashi and M.W. Brechbiel., (2001). Positive Effects of Polyethylene Glycol Conjugation to Generation-4 Polyamidoamine Dendrimers as Macromolecular MR Contrast Agents, Magnetic Resonance in Medicine, 46: 781-788.
Kojima, C., Kono, K., Maruyama, K. and Takagishi, T. (2000). Synthesis of Polyamidoamine Dendrimers having Poly (ethylene glycol) Grafts and their ability to Encapsulate Anti-cancer drugs. Bioconjugate Chemistry, 11: 910-917.
Kolhe, P., Khandare, J., Pillai, O., Kannan, S., Lieh-Lal, M. and Kannan, R. M. (2006). Preparation, Cellular Transport, and Activity of Polyamidoamine-based Dendritic Nanodevices with a High Drug Payload. Biomaterials, 27: 660-669.
Kolhe, P., Misra, E., Kannan, R. M., Kannan, S. and Lieh-Lai, M. (2003). Drug Complexation, in vitro Release and Cellular Entry of Dendrimers and Hyperbranched Polymers, International Journal of Pharmaceutics, 259: 143-160.
Krause, W., Hackmann-Schlichter N., Maier, F.K. and Muller, R., (2000). Dendrimers in Diagnostics. Topics in Current Chemistry, 210: 261-308.
Kubinyi, H. (1995). Strategies and Recent Technologies in Drug Discovery, Pharmazie, 50: 647-662.
Kukowska, Latallo JF, Bielinska AU, Johnson J, Spindler R, Tomalia DA and Baker JR (1996). Efficient Transfer of Genetic Material into Mammalian Cells using Starburst Polyamidoamine dendrimers. Proceedings of the National Academy of Sciences of the United States of America, 93: 4897-4902.
Kwon, G., Naito, M., Yokoyama, M., Okano, T., Sakurai, Y. and Kataoka, K. (1997). Block Copolymer Micelles for Drug Delivery: Loading and Release of Doxorubicin. Journal of Controlled Release, 48: 195-201.
La SB, Okano T and Kataoka K. (1996). Preparation and Characterization of the Micelle-forming Polymeric Drug Indo-methacin-incorporated Poly(ethylene oxide)-poly(beta-benzyl L-aspartate) Block Copolymer Micelles. Journal of Pharmaceutical Sciences, 85: 85-90.
Lach J. L. and Cohen J. (1963). Interaction of Pharmaceuticals with Schardinger Dextrins II. Interaction with Selected Compounds. Journal of Pharmaceutical Sciences, 52: 137-142.
Langer, R. (1998). Drug Delivery and Targeting. Nature 392: 5-10.
Larre, Bressolles D, Turrin C, Donnadieu B, Caminade AM and Majoral JP (1998). Chemistry within Mega Molecules: Regiospecific Functionalization after Construction of Phosphorus Dendrimers. Journal of the American Chemical Society, 120: 13070-13082.
Lee, I., Athey, B. D., Wetzel, A. W., Meixner, W. and Baker, J. R. (2002). Structural Molecular Dynamics Studies on Polyamidoamine Dendrimers for a Therapeutic Application: Effects of pH and Generation, Macromolecules, 35: 4510-4520.
Lipinski, C. A., Lombardo, F., Dominy, B. W. and Feeney, P. J. (2001). Experimental and Computational Approaches to Estimate Solubility and Permeability in Drug Discovery and Setting, Advanced Drug Delivery Reviews, 46: 3-23.
Little, R. C. (1978). Correlation of Surfactant Hydrophilie-Lipo-phile Balance (HLB) with Solubility Paramete. Journal of Colloid and Interface Science, 65: 587-588.
Lu, M., Kono, K. and Frechet, J. M. J. (2000). Journal of Controlled Release. 65: 121-131.
Lorenz, K., Hölter, D., Stühn, B., Mülhaupt, R. and Frey, H., (1996). Amesogen-functionized Carbosilane Dendrimer: a Dendritic Liquid Crystalline Polymer. Advanced Materials, 8: 414-416.
Lyon (1981), Evaluation of Carcinogenic Risk of Chemical to Man, International Agency for Research on Cancer, 26: 267-293.
M. Tamura and H. Fujihara, (2003). Chiral Biophosphine BINAP-Stabilized Gold and Palladium Nanoparticles with Small Size and their Palladium Nanoparticles Catalyzed Desymetric Reaction, Journal of American Chemical Society, 125: 15742-15743.
Mahajeri et al., (2011). Quantitative LC Analysis of Methotrexate and its Application in Pharmacokinetic Study of Drug in Rat Serum Sample. Pharmaclogyonline, 2: 597-604.
Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J. W., Meijer, E. W., Paulus, W. and Duncan, R. (2000), Dendrimers: Relationship between Structure and Biocompatibility in vitro, and Preliminary Studies on the Biodistribution of 125I-labelled Polyamidoamine Dendrimers in vivo. Journal of Controlled Release, 65: 133-148.
Milhem, O. M., Myles, C., McKeown, N. B. and Attwood, D E. (2000). Polyamidoamine Starburst Dendrimers as Solubility Enhancers. International Journal of Pharmaceutics, 197: 239-241.
Miller, L., Duan RG., Tully DC and Tomalia DA (1997). Electrically Conducting Dendrimers, Journal of the American Chemical Society, 1005-1010.
Mohammad N and Antony D. (2006). Crossing Cellular Barriers using Dendrimer Nanotechnologies, Current Opinion in Pharmacology, 6: 522-527.
Morgan, M. T., Carnahan, M. A., Immoos, C. E., Ribeiro, A. A., Finkelstein, S., Lee, S. J. and Grinstaff, M. W. (2003). Dendritic Molecular Capsules for Hydrophobic Compounds. Journal of the American Chemical Society, 125: 15485-15489.
Morgenroth F, Reuther E and Mullen K. (1997). Polyphenylene Dendrimers: From Three-Dimensional to Two-Dimensional Structures, Angewandte Chemie, International Edition in English, 36: 631-634.
Mukerjee, P. (1974). Micellar Properties of Drugs: Micellar and Nonmicellar Patterns of Self-association of Hydrophobic Solutes of Different Molecular Structures--monomer Fraction, Availability, and Misuses of Micellar Hypothesis. Journal of Pharmaceutical Science, 63: 972-981.
Mukerjee, P. and Cardinal, J. R. (1976). Solubilization as a Method for Studying Self-association: Solubility of Naphthalene in the Bile Salt Sodium Cholate and the Complex Pattern of its Aggregation. Journal of Pharmaceutical Sciences, 65: 882-886.
Namazi, H. and Adeli, (2005). Dendrimers of Citric Acid and Poly (ethylene glycol) as the New Drug-delivery Agents. Biomaterials, 26: 1175-1183.
National formulary U.S.P.31, (2009). Asian edition, 3, 2663-2664.
Navath, R. S., Kurtoglu, Y. E., Wang, B., Kannan, S., Romero, R. and Kannan, R. M. (2008). Dendrimer: Drug Conjugates for Tailored Intracellular Drug Release based on Glutathione Levels. Bioconjugate Chemistry, 19: 2446-2455.
Neofotistou, E. and Demadis, K. D. (2004). Use of Antiscalants for Mitigation of Silica Fouling and Diposition: Fundamental and Application in Desalination system. Desalination, 167: 257-272.
Newkome GRM, Baker GR, Saunders MJ, Grossman SH (1991). Uni-molecular Micelles, Angewandte Chemie International Edition in English, 30: 1176-1178.
Ooya, T., Lee, J. and Park, K. (2003). Effect of Ethylene Glycol based Graft Star Shaped and Dendritic Polymers on Solubilization and Controlled Release of Paclitaxel. Journal of Controled Release, 93: 121-127.
P.R. Dvornic, A.M, de Leuze-Jallouli, M.J. Owen and S.V. Perz, (2000), Radially Layer Poly (amidoamine-organosilicon) Copoly-meric Dendrimers and their Networks Containing Controlled Hydrophilic and Hydrophobic Nanoscopic Domains, Chapter 16 in “Silicones and Silicone-Modified Materials”, S.J. Clarson, J.J. Fitzgerald, M.J. Owen and S.D. Smith, Eds., ACS Symposium Series 729, American Chemical Society, Washington DC, 241-269.
Palsson, L. O., Tsiourvas, D., Sideratou, Z. and Tziveleka, L. A. (2008). Multifunctional Dendritic Drug Controlled and Triggered Release, Current Topics in Medicinal Chemistry, 8: 1204.
Patri AK, Majoros IJ and Baker JR (2002). Dendritic Polymer Macromolecular Carriers for Drug Delivery, Current Opinion in Chemical Biology, 6: 466-471.
Pavlov GM, Errington N, Harding SE, Korneeva EV and Roy R (2001). Dilute Solution Properties of Lactosylated Polyamido-amine Dendrimers and their Structural Characteristic, Polymer, 42: 3671-3678.
Peracchia, M. T., Gref, R., Minamitake, Y., Domb, A., Lotan, N. and Langer, R. (1997). PEG-coated Nanospheres from Amphiphilic Diblock and Multiblock Copolymers: Investigation of their Encapsulation and Release Characteristics. Journal of Controlled Release, 46: 223-231.
Perumal, O. P., Inapagolla, R., Kannan, S. and Kannan, R. M. (2008). The Effect of Surface Functionality on Cellular Trafficking of Dendrimers. Biomaterials, 29: 3469-3476.
Petar R. Dvornic, Agnes de Leuze-Jallouli, Michael J. Owen and Susan Perz, (1999). Dendrimer-Based Networks Containing Lyophilic Organosilicon and Hydrophilic Poly (amidoamine) Nanoscopic Domains, United States Patent, 5: 902, 863.
Pistolis, G. and Malliaris, A. (2002). Study of Poly (propylene imine) Dendrimers in Water, by Exciplex Formation. Langmuir, 18: 246-251.
Quintana, A., Raczka, E., Piehler, L., Lee, I., Myc, A., Majoros, I., Patri, A. K., Thomas, T., Mule´, J. and Baker, J. R. (2002), Design and Function of a Dendrimer-based Therapeutic Nano Device Targeted to Tumor Cells through the Folate Receptor. Pharmaceutical Research, 19: 1310-1316.
Rangel-Yagui, C. O., Pessoa, A., Jr. and Tavares, L. C. (2005). Micellar Solubilization of Drugs. Journal of Pharmacy and Pharmaceutical Sciences, 8: 147-163.
Ravindra Semwal et al. (2010). Dendrimers: A Novel Approach for Drug Targeting. Journal of Pharmacy Research 3: 2238-2247.
Rawlinson, C. F., Williams, A. C., Timmins, P. and Grimsey, I. (2007). Polymer-mediated Disruption of Drug Crystallinity. International Journal of Pharmaceutics, 336: 42-48.
Ritzén A and Frejd T (1999). Synthesis of a Chiral Dendrimer based on Polyfunctional Amino Acids, Chemical Communications, 207-208.
Romero, A. J., Rackley, R. J. and Rhodes, C. T. (1991). An evaluation of ibuprofen bioinversion by simulation. Chirality 3: 418-421.
Samaha, M. W., Gadalla, M. A. F. (1987). Solubilization of carbamazepine by different classes of nonionic surfactants and a bile salt. Drug Development and Industrial Pharmacy, 13: 93-112.
Schumann, H., Wassermann, B.C., Schutte, S., Velder, J., Aksu, Y and Krause, W., (2003). Synthesis and Characterization of Water-soluble Tin-based Metallodendrimers. Organometallics, 22: 2034-2041.
Sideratou Z, Tsiourvas D and Paleos CM. (2001). Solubilization and Release Properties of PEGylated Diaminobutane Poly (propylene imine) Dendrimers. Journal of Colloid and Interface Science, 242: 272-276.
Sonke S and Tomalia D.A., (2005). Dendrimers in Biomedical Applications Reflections on the Field. Advanced Drug Delivery Reviews, 57: 2106-2129.
Svenson, S. (2009). Dendrimers as Versatile Platform in Drug Delivery Applications. European Journal of Pharmaceutics and Biopharmaceutics 71: 445-460.
T. Cruz, R. Gaspar, A. Donato and C. Lopes (1997). Interaction between Polyalkylcyanoacrylate Nanoparticles and Peritoneal Macrophages: MTT Metabolism NBT Reduction and NO Production. Pharmaceutical Research, 14: 73-79.
T. G. Schaaff and R. L. Whetten, (2000). Giant Gold−Glutathione Cluster Compounds: Intense Optical Activity in Metal-Based Transitions. Journal of Physical Chemistry, 104: 2630-2641.
Tabakovic I, Miller LL, Duan RG, Tully DC and Tomalia DA (1997), Dendrimers Peripherally Modified with Anion Radicals that form C-dimers and C-stacks. Chemistry of Materials, 9: 736-745.
Tang, M., Redemann, C. T., and Szoka, F. C. (1995). Biophysical and Chemical Determinants of Efficient Gene Delivery by Polyamidoamine Dendrimers. Journal of Cellular Biochemistry, 21: 400-400.
Tolia, G.T., Choi, H.H and Ahsan, F. (2008). The Role of Dendrimers in Drug Delivery. Pharmaceutical Technology, 32: 88-98.
Tomalia D.K., Baker, H. Dewalds and J.R. Halls (1985). A New Class of Polymer Starbust-dendritic Macromolecules. Polymers 7: 117-132.
Tomalia DA, Dewald JR, Hall MR, Martin SJ and Smith PB (1984). Preprints of the 1st SPSJ International Polymer Conference. Society of Polymer Science, Kyoto, Japan, 65.
Tomalia, D.A., (1996). Starburst Dendrimers Nanoscopic Macromolecules according to Dendritic Rules and Principles, Macromolecular Symposia, 101: 243-255.
Topp A, Bauer BJ, Klimash JW, Spindler R, Tomalia DA and Amis EJ, (1999). Probing the Location of the Terminal Groups of Dendrimers in Dilute Solution, Macromolecules, 32: 7226-7231.
Torchilin, V. (2008). Multifunctional Pharmaceutical Nanocarriers: Development of the Concept. In Fundamental Biomedical Technologies, Multifunctional Pharmaceutical Nanocarriers; Springer: New York.
Turnbull, W.B. and Stoddart, J.F., (2002). Design and Synthesis of Glycodendrimers. Reviews in Molecular Biotechnology, 90: 231-255.
Vandamme, T.F and Brobeck, L., (2005). Poly (amidoamine) Dendrimers as Ophthalmic Vehicles for Ocular Delivery of Pilocarpine Nitrate and Tropicamide, Journal of Controlled Release, 102: 23-38.
Vutukuri, D. R., Basu, S. and Thayumanavan, S. (2004). Dendrimers with both Polar and Apolar Nanocontainer Characteristics. Journal of the American Chemical Society, 126: 15636-15637.
Wang, C., Wyn-Jones, E., Sidhu, J. and Tam, K. C. (2007) Supramolecular Complex Induced by the Binding of Sodium Dodecyl Sulfate to PAMAM Dendrimers. Langmuir, 23: 1635-1639.
Whitworth, C. W. and Carter, E. R. (1969). Effect of Certain Nonionic Surfactants on the Absorption of Salicylic Acid from Solutions by the Frog, Rana Pipiens. J Pharm Sci, 58: 1285-1287.
Wiener, E.C., Brechbiel, M.W, Brothers, H., Magin, R.L., Gansow, O.A and Tomalia, D.A., (1994). Dendrimer-based Metal Chelates: a New Class of Magnetic Resonance Imaging Contrast Agents. Magnetic Resonance in Medicine, 31: 1-8.
Wiener, E.C., Konda, S., Shadron, A., Brechbiel, M and Gansow, O., (1997). Targeting Dendrimer– Chelates to Tumors and Tumor Cells Expressing the High Affinity Folate Receptor. Investigative Radiology, 32: 748-54.
Wilken R and Adams J (1997). End Group Dynamics of Fluorescently Labeled Dendrimers, Macromolecular Rapid Communications, 7: 659-665.
Williams, K., Day, R., Knihinicki, R. and Duffield, A. (1986). The Stereo Selective uptake of Ibuprofen Enatiomers into Adipose Tissue, Biochemical Pharmacology, 35: 3403-3405.
Wiwattanapatapee, R., Jee, R. D. and Duncan, R. (1999). Drug Complexation, in vitro Release and Cellular Entry of Dendrimers and hyperbranched polymers, Proceedings International Symposium Control Related to Bioactive Materials, 26: 241.
Wooley KL, Hawker CJ and Frechet JMJ (1993). Unsymmetrical three Dimensional Macromolecules: Preparation and Characterization of Strongly Dipolar Dendritic Macromolecules. Journal of the American Chemical Society, 43: 11496-11505.
Yang, J., Morris, S. and Lopina, T. (2004). Polyethylene Glycol Lpolyamidoamine Dendritic Micelle as Solubility Enhancer and the Effect of the Length of Polyethylene Glycol Arms on the Solubility of Pyrene in Water. Journal of Colloid and Interface Science, 273: 148–154.
Yiyun C, Zhenhua X, Minglu M and Tonguen X (2008). Dendrimers as Drug Carriers: Applications in Different Routes of Drug. Journal of Pharmaceutical Sciences, 97: 123-143.
Yiyun, C. and Tongwen, X. (2005). Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-steroidal Anti-Inflammatory Drugs in the Presence of Polyamidoamine Dendrimers. European Journal of Medicinal Chemistry, 40: 1188-1192.
Yiyun, C. and Tongwen, X. (2005). Solubility of Nicotinic Acid in Polyamidoamine Dendrimer Solutions. European Journal of Medicinal Chemistry, 40: 1384-1389.
Yiyun, C. and Tongwen, X. (2005). Polyamidoamine Dendrimers used as Solubility Enhancers of Ketoprofen. European Journal of Medicinal Chemistry, 40: 1390-1393.
Yu, B. G., Okano, T., Kataoka, K. and Kwon, G. (1998). Polymeric Micelles for Drug Delivery; Solubilization and Haemolytic Activity of Amphotericine B. Journal of Controlled Release, 53: 131-136.
Zeng F, Zimmerman SC, Kolotuchin SV, Reichert DEC and Ma Y, (2002). Supramolecular Polymer Chemistry: Design, Synthesis, Characterization, and Kinetics, Thermodynamics, and Fidelity of Formation of Self-assembled Dendrimers. Tetrahedron, 58: 825- 843.
Zhang, Z. Y., and Smith, B. D. (2000). High-generation Polycationic Dendrimers are Unusually Effective at Disrupting Anionic Vesicles: Membrane Bending Model. Bio Conjugate Chemistry, 11: 805-814.
Zhuo RX, Du B and Lu ZR (2004). In vitro Release of 5-fluorouracil with Cyclic Core Dendritic Polymer. Journal of Controlled Release, 57: 249-257.
