Recent Advances in Microspheres Technology for Drug Delivery
DOI:
https://doi.org/10.37285/ijpsn.2015.8.2.2Abstract
Microspheres are the novel drug delivery system. A well considered controlled drug delivery system can overcome some of the problems of predictable therapy and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release approach. A Microspheres has its drug dispersed throughout the particle i.e., the internal structure is a matrix of drug and polymeric excipients. It is the reliable means to deliver the drug to the target site with specificity, if modified and to maintain the desired concentration at the site of interest without untoward effects. Microspheres are typically free flowing powders consisting of synthetic polymers which are biodegradable in nature. Microspheres are particles between 0.1 and 200 μm in size. Microspheres received much consideration not only for prolonged release, but also for targeting of anticancer drugs to the tumor. Microspheres are spherical microparticles and are used where reliable and expected particle surface area is important. A microsphere has a drug located centrally within the particle, where it is encased within a unique polymeric membrane. In future by combining various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in-vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.
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Keywords:
Drug delivery systems, Controlled release, Microspheres, Therapeutic efficacy
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