Formulation and Evaluation of Trilayered Tablets of Zolmitriptan
DOI:
https://doi.org/10.37285/ijpsn.2016.9.6.1Abstract
The present study outlines a systematic approach to formulate and evaluate trilayered tablets of zolmitriptan by geomatrix technology by using different concentrations of HPMC, xanthangum and ethyl cellulose by direct compression method for controlled release, which may produce the controlled drug release in the treatment of migraine disorder. The different release rates from these formulations were obtained from in vitro dissolution studies. From the results it was observed that the release rate was greatly influenced by the polymer concentration. In order to obtain a formulation which releases more than 90% of drug within 12-14hrs, sixteen formulation trials of the active layer have been prepared and the drug release follows first order kinetics. Hence, the formulation trial F14 showed about 99% drug release in 12 hrs, where the drug release was dependent on concentration of drug in tablets and showed various physiochemical evaluation parameters like hardness, thickness and also showed drug excipient compatibilities by DSC and FTIR studies.
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Keywords:
Zolmitriptan, Geomatrix technology, Direct compression, DSC, FTIR
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References
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