Prevalence of Vitamin-D Deficiency in Patients with Acute Coronary Syndrome in Syria

DOI:

https://doi.org/10.37285/ijpsn.2016.9.6.5

Authors

  • Aya Hallak
  • Malhis Mahmoud
  • Yaser Abajy Mohammad

Abstract

The objectives of this study were to estimate the prevalence of vitamin D deficiency in patients with acute coronary syndrome in comparison with normal individuals and study the correlation between these two conditions. We measured the plasma 25-hydroxy vitamin D (25-OH-D) levels in 60 patients with acute coronary syndromes (ACS) of both gender and in 30 age matched control individuals of both gender without any known cardiovascular or systemic diseases. The levels of 25-OH-D were measured by ELISA method and the results were statically analyzed to find out any possible correlation. We classified the cases according to their plasma 25(OH)D levels. 25(OH)D levels of ≥ 30 ng/ml were considered normal, levels < 30 and > 20 ng/ml were classified as insufficient, while levels of ≤ 20 ng/ml were classified as deficient. In the current study the prevalence of hypovitaminosis D in the patients group was much higher than it was in the control group. Vitamin D deficiency was observed in 80% and insufficiency in 13% of total patients of ACS, there by bringing the total count to 93%. Whereas only 7% of the patients had adequate vitamin D levels. Thus, these results indicate the existence of a significant correlation between the vitamin D deficiency and ACS in comparison to healthy controls

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Keywords:

Vitamin D Deficiency, Cardiovascular, Acute Coronary Syndrome, Prevalence

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Published

2016-11-30

How to Cite

1.
Hallak A, Mahmoud M, Mohammad YA. Prevalence of Vitamin-D Deficiency in Patients with Acute Coronary Syndrome in Syria. Scopus Indexed [Internet]. 2016 Nov. 30 [cited 2024 Dec. 22];9(6):3544-8. Available from: https://ijpsnonline.com/index.php/ijpsn/article/view/892

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Section

Research Articles

References

Aihara K, Azuma H, Akaike M, Ikeda Y, Yamashita M, Sudo T, HayashiH, Yamada Y, Endoh F, Fujimura M, Yoshida T, Yamaguchi H,Hashizume S, Kato M, Yoshimura K, Yamamoto Y, Kato S and MatsumotoT (2004). Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicityin mice. J Biol Chem 279: 35798-35802.

Autier P and Gandini S (2007). Vitamin D supplementation and total mortality: ameta-analysis of randomized controlled trials. Arch Intern Med 167: 1730-1737.

Bringhurst FR, Demay MB, Krane SM and Kronenberg HM (2012). Boneand mineral metabolism in health and disease. In Harrison’s principles of internal medicine (Longo DL,Fauci AS, Kasper DL, Hauser SL, Jameson JL and Loscalzo Jeds), eighteenthedition, McGraw Hill, pp 3082-5.

Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ and Vieth R (2005). Estimates of optimal vitamin D status. Osteoporos Int 16: 713- 6.

Douglas AS, Dunnigan MG, Allan TM and Rawles JM (1995).Seasonal variation incoronary heart disease in Scotland. J Epidemiol Community Health 49: 575-82.

Forman JP, Giovannucci E, Holmes MD, Bischoff-Ferrari HA, Tworoger SS, Willett WC and Curhan GC(2007). Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 49: 1063-9.

Giovannucci E, Liu Y, Hollis BW and Rimm EB (2008). 25-Hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. ArchIntern Med 168: 1174-1180.

Grimes DS, Hindle E and Dyer T (1996). Sunlight, cholesterol and coronary heart disease. QJM 89: 579-89.

Kim DH, Sabour S, Sagar, Adams S and Whellan DJ (2008). Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004). Am J Cardiol 102: 1540-4.

Lee JH, Gadi R, Spertus JA, Tang F and O'Keefe JH (2011). Prevalence of vitamin D deficiency in patients with acute myocardialinfarction. Am J Cardiol 107(11): 1636-8.

Lee JH, O’Keefe JH, Bell D, Hensrud DD and Holick MF (2008). Vitamin Ddeficiency: an important, common, and easily treatable cardiovascularrisk factor? J Am Coll Cardiol 52: 1949-1956.

Li YC, Kong J, Wei M, Chen ZF, Liu SQ and Cao LP (2002). 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110: 229-238.

Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, Felsenfeld A, Levine B, Mehrotra R and Norris K. (2007). Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Healthand Nutrition Examination Survey. Arch Intern Med 167: 1159-65.

Mirghani HO, Mohammed OS and Alyoussuf AA (2015). Vitamin D deficiency among patients with acute coronary syndrome and its relation to in-hospital complications. Indian J Applied Research 5: 843-5.

Mitsuhashi T, Morris RC Jr and Ives HE (1991). 1, 25-Dihydroxyvitamin D3 modulates growth of vascular smooth muscle cells. J Clin Invest 87: 1889-1895.

Moradzadeh K, Larijani B, Keshtkar AA, Hossein-nezhad A, Rajabian R, Nabipour I, Omrani GH, Bahrami A, Gooya MM and Delavari A (2008). Normative value of vitamin D among Iranian population: a population based study. Int J Osteoporosis Metab Disord 1(1): 8-15.

O’Connell TD, Berry JE, Jarvis AK, Somerman MJ and Simpson RU (1997). 1,25- Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy. Am J Physiol 272: H1751–H1758.

Pilz S, Dobnig H, Fischer JE, Wellnitz B, Seelhorst U, Boehm BO and Marz W (2008(a)). Low vitamin D levels predict stroke in patients referred tocoronary angiography. Stroke 39: 2611-2613.

Pilz S, Marz W, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai HP, Boehm BO and Dobnig H (2008(b)). Association of vitamin D deficiency with heart failure and sudden cardiac death in a large crosssectionalstudy of patients referred for coronary angiography. J ClinEndocrinol Metab 93: 3927-3935.

Rigby WF, Denome S and Fanger MW (1987). Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3: specific inhibition at the level of messenger RNA. J Clin Invest 79: 1659-1664.

Rosen CJ (2011). Vitamin D insufficiency. N Engl J Med 364: 248-254.

Rostand SG (1997).Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension 30: 150-6.

Sigmund CD, Okuyama K, Ingelfinger J, Jones CA, Mullins JJ, Kane C, Kim U, Wu CZ, Kenny L and Rustum Y (1990). Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. J Biol Chem 265: 19916-19922.

Somjen D, Weisman Y, Kohen F, Gayer B, Limor R, Sharon O, Jaccard N, Knoll E and Stern N (2005). 25-Hydroxyvitamin D3-1α-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroidhormone and estrogenic compounds. Circulation 111: 1666-1671.

Teng M, Wolf M, Ofsthun MN, Lazarus JM, Hernan MA, Camargo CA Jr and Thadhani R (2005). Activated injectable vitamin D and hemodialysis: a historical cohort study. J Am Soc Nephrol 16: 1115-1125.

Thomas GN, Hartaigh B, Bosch JA, Pilz S,Loerbroks A, Kleber ME, Fischer JE, Grammer TB, Bohm BO and Marz W(2012). Vitamin D levels predict all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome: The Ludwigshafen Risk and Cardiovascular Health (LURIC) Study. DiabetesCare 35(5): 1158-64.

Wallis DE, Penckofer S and Sizemore GW (2008). The “sunshine deficit” andcardiovascular disease. Circulation 118: 1476-1485.

Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D’Agostino RB, Wolf M and Vasan RS (2008). Vitamin D deficiency and risk of cardiovascular disease. Circulation 117: 503-511.

Welles CC, Whooley MA, Karumanchi SA, Hod T, Thadhani R, Berg AH, Ix JH and Mukamal KJ (2014). VitaminD deficiency and cardiovascular events in patients with coronary heart disease: data from the heart and soul study. Am J Epidemiol 180(7): 762.

Wolf M, Shah A, Gutierrez O, Ankers E, Monroy M, Tamez H, Steele D, Chang Y, Camargo CA Jr, Tonelli M and Thadhani R (2007). Vitamin D levels and early mortality among incident hemodialysis patients.Kidney Int 72: 1004-1013.

Wu J, Garami M, Cao L, Li Q and Gardner DG (1995). 1,25(OH)2D3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes. Am J Physiol 268(pt 1): E1108-E1113.

Xiang W, Kong J, Chen S, Cao LP, Qiao G, Zheng W, Liu W, Li X, Gardner DG and Li YC (2005). Cardiac hypertrophy in vitamin D receptor knockout mice: role of the systemic and cardiac renin-angiotensin systems. Am J Physiol Endocrinol Metab 288: E125-E132.

Young KA, Snell-Bergeon JK, Naik RG, Hokanson JE, Tarullo D, Gottlieb PA, Garg SK and Rewers M (2011).Vitamin D deficiency and coronary artery calcification in subjects with type 1 diabetes. Diabetes Care 34: 454-8.

Zehnder D, Bland R, Chana RS, Wheeler DC, Howie AJ, Williams MC, Stewart PM and Hewison M (2002). Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion. J Am Soc Nephrol 13: 621-629.

Zittermann A, Schleithoff SS and Koerfer R (2005).Putting cardiovascular disease andvitamin D insufficiency into perspective. Br J Nutr 94: 483-92.

Zittermann A, Scheld K and Stehle P (1998).Seasonal variations in vitamin D statusand calcium absorption do not influence bone turnover in young women. Eur JClin Nutr 52: 501-6.

Zittermann A (2006). Vitamin D and disease prevention with special referenceto cardiovascular disease. Prog Biophys Mol Biol 92: 39-48.