Neurotherapeutic Role of Nanomedicines in the Mitigation of Amyloid-Tau Peptides
DOI:
https://doi.org/10.37285/ijpsn-aktu.2022-06Abstract
Alzheimer’s disease, one of the commonest neurodegenerative disorders affecting the elderly throughout the globe. A person with AD experiences severe memory loss as the condition worsens and becomes unable to do basic tasks. Signs of mental disorientation, such as confusion, difficulty understanding and thinking, forget-fulness, trouble concentrating, repetition of words, personality changes, mood swings, depression, hallucination, jumbled speech, and loss of appetite are seen. In AD, free radical damage from reactive oxygen radicals like hydroxyl radical, hydrogen peroxide, nitric oxide, and super anions leads to neurodegeneration. Detrimental effect on lipids, proteins, and DNAs are just a few negative impacts caused by ROS. Antioxidants, however, scavenge ROS. Amyloid, which forms plaques around brain cells, and tau, which forms tangles inside brain cells, are examples of proteins that accumulate abnormally and contribute to AD. Unusual tau phosphorylation results into the development of aberrant neurofibrillary structures. It has been established that β-amyloid plays a remarkable role in the neurodegeneration associated with AD, which causes oxidative stress in the brain. Nanotechnology uses nanoparticles that acts as a drug delivery system and with the help of lipid based, polymeric based, and inorganic nanoparticles help in the sustained release of drugs at a specific location.
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Alzheimer, nanotechnology, tau protein, β-amyloidPublished
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